Steven Dzul

Physician (Radiation Oncology), Beaumont Hospital, Dearborn, MI

Education: B.S.E in Chemical Engineering, University of Michigan-Ann Arbor
Graduate Program Affiliation: Biochemistry and Molecular Biology
Research Interests: FeS-Cluster Biogenesis via the Eukaryotic FeS-Cluster pathway (ISC), Biophysical characterization of metal-binding sites in metalloproteins.
Advisor: Timothy Stemmler, Ph.D.

Publications/Presentations:

1. Blahut, M.; Dzul, S.; Wang, S.;Kandegedara, A.; Grossoehmec, N.; Stemmler, T.; Outten, FW. Conserved cysteine residues are necessary for nickel-induced allosteric regulation of the metalloregulatory protein YqjI (NfeR) in E. coli. J Inorg Biochem. 2018; 184: 123-133.

2. Truong, P.; Gale, E.; Dzul, S. P.; Stemmler, T. L.; Harrop, T. C., Steric Enforcement About One Thiolate Donor Leads to New Oxidation Chemistry in NiSOD. J Inorg Chem. 2017;  56(14): 7761-7780.

3. Steiner, R. A.; Dzul, S. P.; Stemmler, T. L.; Harrop T. C., Synthesis and Speciation-Dependent Properties or a Multimetallic Model Complex of NiSOD That Exhibits Unique Hydrogen-Bonding. J Inorg Chem. 2017; 56(5): 2849-2862.

4. Dzul, S. P.; Rocha A. G.; Rawat, S.; Kandegadara, A.; Kusowski, A.; Pain, J.; Murari, A.; Pain, D.; Dancis, A.; Stemmler, T. L., In vitro characterization of a novel Isu homologue from D. Melanogaster for de novo FeS-cluster formation. Metallomics. 2016; 9(1): 48-60.

5. Walter, M. R.; Dzul, S. P.; Rodrigues, A. V.; Stemmler, T. L.; Telser, J.; Conradie, J.; Ghosh A.; Harrop, T. C., Synthesis of Co-NO complexes and their reactivity as a source of hydroxyl. J Biol Chem. 2016; 138: 12459-12471.

6. Dzul, S. P.; Barupala, D. P.; Riggs-Gelasco, P. J.; Stemmler, T. L., Synthesis, delivery and regulation of eukaryotic heme and Fe-S cluster cofactors. Arch Biochem Biophys. 2016; 592: 60-75.

7. Dzul, S. P.; Stemmler, T. L.; Penner-Hahn, J.E. “Manganese Proteins with Mono- and Dinuclear Metal Sites”. Encyclopedia of Inorganic and Bioinorganic Chemistry, Robert A. Scott Eds., Chichester, UK: John Wiley & Sons, Ltd., 2015.

8. Bafaro, E. M.; Antala, S.; Nguyen, T. V.; Dzul, S. P.; Doyon, B.; Stemmler, T. L.; Dempski, R. E., The large intracellular loop of hZIP4 is an intrinsically disordered zinc binding domain. Metallomics. 2015; 7: 1319-1330.

9. Plegaria, J. S.; Dzul, S. P.; Zuiderweg, E. R.; Stemmler, T. L.; Pecoraro, V. L., Apoprotein Structure and Metal Binding Characterization of a de Novo Designed Peptide, alpha3DIV, that Sequesters Toxic Heavy Metals. Biochemistry. 2015; 54: 2858-2873.

10. Byrne, E.; Dzul, S.; Solomon, M.; Younger, J.; Bortz, D. M., Postfragmentation density function for bacterial aggregates in laminar flow. Phys Rev E Stat Nonlin Soft Matter Phys. 2011; 83: 041905.

11. Dzul, S. P.; Thornton, M. M.; Hohne, D. N.; Stewart, E. J.; Shah, A. A.; Bortz, D. M.; Solomon, M. J.; Younger, J. G., Contribution of the Klebsiella pneumoniae capsule to bacterial aggregate and biofilm microstructures. Appl Environ Microbiol. 2011; 77: 1777-1782.

Awards:
Dorothy and Charles Pokriefka Scholarship. 2018.
Best Oral Presentation. First place. MD/PhD Research Day. 2016.
Best Oral Presentation: Second place. Biochemistry Research Forum. 2015.
Outstanding Achievement. Medical Student Recognition Day. 2014.
Thomas Rumble University Graduate Fellowship. 2012.
Henry Ford Health Systems Student Medical Scholarship. 2011.

Funding: 
2014-2018 National Institute of Health: 1F30DK101230-01A1 Dzul (PI) Characterizing Isu Scaffolding Protein and ISC Multiprotein Complex. Total award: $179,000.

2013-2014 American Heart Association: 13PRE16490009 Dzul (PI) Characterizing Isu Scaffolding Protein and ISC Multiprotein Complex. Total award: $52,000.

Residency Match: Radiation Oncology, Detroit Medical Center, Wayne State University