Olga Astapova

Assistant Profesor, Department of Medicine, University of Rochester Medical Center

Education: BS University of Michigan, Biochemistry
Graduate Program Affiliation: Pathology
Research Interests: Biology of reproduction
Clinical Interests: Gynecology
AdvisorTodd Leff, Ph.D., Pathology


  1. Veiga-Lopez A, Astapova OI, Aizenberg EF, Lee JS, Padmanabhan V (2009) Developmental programming: contribution of prenatal androgen and estrogen to estradiol feedback systems and periovulatory hormone dynamics in sheep. Biology of Reproduction 80(4):718-25
  2. Savabieasfahani M, Kannan K, Astapova OI, Evans NP, and Padmanabhan V (2006) Developmental programming: differential effects of prenatal exposure to bisphenol-A or methoxychlor on reproductive function. Endocrinology 147(12):5956-66

Book Chapters:

  1. Astapova, O. and Leff, T. (2009) PPAR: A Key Regulator of Adipose Tissue Formation, Remodeling and Metabolism. in Adipose Tissue in Health and Disease. Wiley-VCH, Weinheim, Germany.


  1. Astapova OI, Bergeron J, Campeau PM, Couture P, Gagne C, Hegele RA, and Leff TA (2010) Mechanistic Studies of a Diabetes-Associated Mutation in the DNA Binding Domain of Human PPARγ. 70th Scientific Sessions of the American Diabetes Association, Orlando, FL. in press
  2. Astapova OI, Herkimer CH, Olton PO, Lee JS, Flak J, and Padmanabhan V (2006) Developmental Programming: defects in preovulatory estradiol rise and gonadotropin surge dynamics in prenatal testosterone-treated ewes are not programmed by androgenic action of testosterone. 39th Annual Meeting, Society for the Study of Reproduction. Omaha, NE. Biol Reprod Special Issue p 77 (Abstract 28)
  3. Astapova OI, Steckler T, Lee TM, Jackson LM, and Padmanabhan V (2005) Fetal programming: Advanced placentome differentiation in testosterone-treated sheep is facilitated by androgenic actions of testosterone. 38th Annual Meeting, Society for the Study of Reproduction. Quebec City, QC, Canada. Biol Reprod 70 (Suppl. 1), 209.

2009 Graduate Student Research Award-WSU
2008-2009 MD PhD Student Representative-WSU
2007 Medical Student Research Symposium ( MD PhD), Second Place-WSU
2006 USDA National Research Initiative Fellow

F30 Fellowship 1F30DK083195-01A2
National Institutes of Health
Title: Mechanistic studies of a PPAR-gamma mutation that causes lipodystrophy & diabetes
Issue Date: 09/04/2009

Outside Interests: Music, books, and food

Favorite Aspects of MD PhD Program: Very nice people and lots of support from the program administration and faculty