David Bissig

Assistant Professor, Department of Neurology, UC Davis Medical Center

Education: BS University of Michigan-Ann Arbor, Psychology & Philosophy
Graduate Program Affiliation: Anatomy & Cell Biology
Research Interests: Artificial Vision
Clinical Interests: Neurology
AdvisorBruce Berkowitz, PhD


  1. Berkowitz BA, Bissig D, Dutczak O, Corbett S, North R, Roberts R. MRI biomarkers for evaluation of treatment efficacy in preclinical diabetic retinopathy. Expert Opin Med Diagn. 2013 Jul;7(4):393-403. Epub 2013 Jun 21.
  2. Bissig D, Goebel D, Berkowitz BA. Diminished Vision in Healthy Aging is Associated with Increased Retinal L-type Voltage Gated Calcium Channel Ion Influx. PLoS One. 2013;8(2):e56340. Epub 2013 Feb 14.
  3. Bissig D, Berkowitz BA. Light-dependent changes in outer retinal water diffusion in rats in vivo. Mol Vis. 2012;18:2561-xxx. Epub 2012 Oct 19.
  4. Chui TY, Bissig D, Berkowitz BA, Akula JD. Refractive Development in the “ROP Rat”. J Ophthalmol. 2012;2012:956705. Epub 2012 Feb 8.
  5. Li X, McClellan ME, Tanito M, Garteiser P, Towner R, Bissig D, Berkowitz BA, Fliesler SJ, Woodruff ML, Fain GL, Birch DG, Khan MS, Ash JD, Elliott MH. Loss of caveolin-1 impairs retinal function due to disturbance of subretinal microenvironment. J Biol Chem. 2012 May 11;287(20):16424-34. Epub 2012 Mar 26.
  6. Braun RD, Bissig D, North R, Vistisen KS, Berkowitz BA. Human tumor cell proliferation evaluated using manganese-enhance MRI. PLoS One. 2012;7(2):e30572. Epub 2012 Feb 17.
  7. Berkowitz BA, Bissig D, Patel P, Bhatia A, Roberts R. Acute systemic 11-cis-retinal intervention improves abnormal outer retinal ion channel closure in diabetic mice. Mol Vis. 2012;18:372-6. Epub 2012 Feb 7.
  8. Berkowitz BA, Bissig D, Ye Y, Valsadia P, Kern TS, Roberts R. Evidence for diffuse central retinal edema in vivo in diabetic male Sprague Dawley rats. PLoS One. 2012;7(1):e29619. Epub 2012 Jan 11.
  9. Bissig D, Berkowitz B.A. Same-session functional assessment of rat retina and brain with manganese-enhanced MRI. NeuroImage. 2011; 58(3):749-60.
  10. Berkowitz B.A., Bissig D., Bergman D., Bercea E., Kastur V.K., Roberts R. Intraretinal calcium channels and retinal morbidity in experimental retinopathy of prematurity. Mol Vis. 2011; 17:2516-26. PMCID: PMC3185031.
  11. Holt A.G., Bissig D., Mirza N., Rajah G., Berkowitz B.A. Evidence of key tinnitus-related brain regions documented by a unique combination of manganese-enhanced MRI and acoustic startle reflex testing. PLoS One. 2010; 5(12):e14260. PMIC: PMC3002264.
  12. Berkowitz B.A., Roberts R., Bissig D. Light-dependant intraretinal ion regulation by melanopsin in young awake and free moving mice evaluated with manganese-enhanced MRI. Mol Vis. 2010; 16:1776-80. PMCID: PMC2929942.
  13. Ivanova E., Roberts R., Bissig D., Pan Z-H., Berkowitz B.A. Retinal channelrhodopsin-2-mediated activity in vivo evaluated with manganese-enhanced magnetic resonance imaging.
  14. Berkowitz B.A., Gradianu M., Bissig D., Kern T.S., Roberts R., 2009. Retinal ion regulation in a mouse model of diabetic retinopathy: Natural history and the effect of Cu/Zn superoxide dismutase overexpression. Investigative Ophthalmology & Visual Science, 50(5), 2351-2358. PMCID: PMC2688071
  15. Berkowitz B.A., Roberts R., Oleske D.A., Chang M., Schafer S., Bissig D., Gradianu M., 2009. Quantitative mapping of ion channel regulation by visual cycle activity in rodent photoreceptors in vivo, Investigative Ophthalmology & Visual Science, 50(4), 1880-1885. PMCID: PMC2696261
  16. Bissig D., Berkowitz B.A., 2009. Manganese-enhanced MRI of layer-specific activity in the visual cortex from awake and free-moving rats. NeuroImage, 44(3), 627-637. PMCID: PMC2642584
  17. Berkowitz B.A., Roberts R., Luan H., Bissig D., Bui B.V., Gradianu M., Vingrys A.J., 2007. Manganese-enhanced MRI studies of alterations of intraretinal ion demand in models of ocular injury, Investigative Ophthalmology & Visual Science 48(8): 3796-3804. PMCID: PMC2041849
  18. Bissig D., Lustig C. 2007. Who benefits from memory training? Psychological Science, 18(8): 720-726


  1. Bissig, D., Berkowitz,B., (October, 2009). Manganese-enhanced MRI of retinal and central visual system activity in the rat. Abstract for poster presentation, Society for Neuroscience Annual Meeting, Chicago, Il.
  2. Berkowitz, B.A., Roberts,R., Luan,H., Bissig,D., Bui,B.V., Vingrys,A.J., Gradianu,M., (May 2007). Manganese-enhanced MRI studies of intraretinal dyshomeostasis. Abstract for poster presentation, The Association for Research in Vision and Ophthalmology Annual Meeting, Fort Lauderdale, FL.
  3. Askren, M., Bissig,D., Lustig,C., (May, 2007). Do breakdowns in interhemispheric processing contribute to age differences in emotion recognition? Abstract for poster presentation, Cognitive Neuroscience Society Annual Meeting, New York, NY.
  4. Bissig, D., Walsh,M., Reinink,A., Lustig,C., (April 2006). Who benefits from memory training? Impact of individual differences in strategy use. Abstract for poster presentation, Cognitive Aging Conference, Atlanta, GA.


  1. Reviewer for Behavioral Brain Research, 2010
  2. NeuroImage Editor’s Choice Award (for Bissig & Berkowitz, NeuroImage, 44(3), 627-637), 2009
  3. Board of Governors Medical Scholarship, Wayne State University, 2006-2008

Professional Memberships/Societies:
Membership in the American Medical Association, 2006-present
Membership in the Michigan Chapter of the Society for Neuroscience, 2009
Membership in the Society for Neuroscience, 2009

F30 Grant
National Institute of Aging
Score: 10
Submission December 2009

Outside Interests: Reading, Painting