Biography

Education:

The Johns Hopkins University, Baltimore, MD
Master of Science in Biotechnology

University of Pittsburgh, Pittsburgh, PA
Bachelor of Science in Chemistry and Molecular Biology (Dual Majors)

Year in Program: M3

Mentor: Qing-Sheng Mi, MD/PhD

Funding:

NIH/NIGMS F30 Ruth L. Kirschstein Individual Predoctoral NRSA

Thomas C. Rumble Fellowship, Wayne State University 2020-2022

 

Research Interests

I study the epigenetic regulation of inflammatory and immunoproliferative diseases. In my research I employ single-cell epigenomics and genetic mouse models to better understand how oncogene-induced dysregulation of myeloid cells leads to therapeutic vulnerabilities. I’m also working to better understand how genetic variation leads to altered immune responses in an autoinflammatory skin disease, hidradenitis suppurativa. The goal is to better character patient heterogeneity and enhance personalized medicine approaches to treating patients with hidradenitis suppurativa.

Honors and Awards

The Jon D. Pritchard Award, 2024
The Leonard N. Simons Award for Exemplary Research and Scholarly Achievement, 2024
Abstract Achievement Award, Karmanos Tumor Biology and Microenvironment Retreat, 2023
HFCI Cancer Research Advisory Group AACR Travel Scholarship, 2023
American Society of Hematology Abstract Achievement Award, 2023
Best Abstract in Emerging Technologies & ‘Omics Research, HFHS Research Symposium, 2023
3rd Place Abstract Award Cancer Biology Research Symposium, 2023
Cancer Biology Graduate Program Travel Award, 2023
WSUSOM MD/PhD Travel Award, 2023
Cancer Biology Graduate Program Travel Award, 2022
WSUSOM MD/PhD Travel Award, 2022
Best Abstract & Oral Presentation, HFHS Research Symposium, 2021
Jerry A & Mary D Martin Memorial Scholarship, Northwest AHEPA Family Educational Foundation, 2020
Superior Hospital Alignment Prize, Quest Research Symposium, 2020
Dean’s List, 2012-2016, University of Pittsburgh
Departmental Honors, University of Pittsburgh Department of Chemistry, 2016
The Chris Papadimitrakis Scholarship, 2011

 

 

Publications

1. Bielamowicz K.*, Dimitrion,P.*, Abla, O., Bomken, S., Campbell, P., Collin, M., Degar, B., Diamond, E., Eckstein, O., El-Mallawany, N., Fluchel, M., Goyal, G., Henry, M.M., Hermiston, M., Hogarty, M., Jeng, M., Jubran, R., Lubega, J., Kumar, A., McClain, K.L., Merad, M., Mi, Q.S., Parsons, D.W., Peckham-Gregory. E., Ladisch, S., Picarsic, J., Rollins, B., Westinghausen, B., Rodriguez-Galindo, C., Allen, C.E. on behalf of the North American Consortium for Histiocytosis. Langerhans Cell Histiocytosis: NACHO Update on Progress and Chaos on the Path to Rationale Cures Cancer (Accepted); 2024.
2. Veenstra, J., Ozog, D., Loveless, I., Adrianto, I., Dimitrion, P., Subedi, K., Friedman, B., Zhou, L., Mi, QS. Distinguishing keratoacanthoma from well-differentiated cutaneous squamous cell carcinoma using single-cell spatial pathology. J Invest Dermatol. Published online July 5, 2023:S0022-202X(23)02398-9.
3. Dimitrion P., Loveless I., Zhou L., Mi QS., Adrianto I. An Integrative ‘Omics Database for Hidradenitis Suppurativa Research. J. Invest. Derm. Jun 2:S0022-202X(23)02137-1. doi: 10.1016/j.jid.2023.05.013
4. Dimitrion P., Hamzavi I., Loveless I., Yin C., Toor J., Subedi K., Khalasawi N., Yao Y., Miller A., Huggins R., Adrianto I., Veenstra J., Vellaichamy G., Hans A., Daveluy S., Athar M., Liao W., Lim H., Ozog D., Zhou L., Mi QS. Dysregulated CD38 expression in blood and skin immune cells of patients with hidradenitis suppurativa. Cell Mol Immunol. 2023 May 29. doi: 10.1038/s41423-023-01037-6
5. Hengy M, Farooqui S, Dimitrion P, Fotouhi A, Daveluy S. Leadership training in dermatology: a narrative review. Int J Dermatol. Published online November 23, 2022.
6. Vellaichamy G, Amin AT, Dimitrion P, Hamzavi Z., Zhou L., Adrianto I., Mi QS. Recent advances in hidradenitis suppurativa: Role of race, genetics, and immunology. Front Genet. 2022;13:918858.
7. Yao Y, Subedi K, Liu T, Khalasawi N., Pretto-Kernahan CD., Wotring JW., Wang J., Yin C., Jiang A., Fu C., Dimitrion P., Li J., Veenstra J., Yi Q., McKinnon K., McKinnon JE., Sexton JZ., Zhou L. Mi QS. Surface translocation of ACE2 and TMPRSS2 upon TLR4/7/8 activation is required for SARS-CoV-2 infection in circulating monocytes. Cell Discov. 2022;8(1):89.
8. Li L, Halpert G, Lerner MG, Haije H, Dimitrion P., et al. Protein synthesis inhibitor omacetaxine is effective against hepatocellular carcinoma. JCI Insight. 2021;6(12):e138197.
9. Veenstra, JV, Dimitrion P, Yao Y, Zhou L, Ozog D, Mi QS. Research Techniques Made Simple: Use of Imaging Mass Cytometry for Dermatological Research and Clinical Applications. J. Invest. Dermatol (Accepted, 2021)
10. Vellaichamy G, Dimitrion P, Zhou L, Ozog D, Lim H, Liao W, Hamzavi I, Mi QS. Insights from γ-secretase: Functional Genetics of Hidradenitis Suppurativa. J. Invest. Dermatol (Accepted, 2021)
11. Zierden HC, Ortiz JI, DeLong K, Yu J, Li G, Dimitrion P et. al. Enhanced drug delivery to the reproductive tract using nanomedicine reveals therapeutic options for prevention of preterm birth. Science Translational Medicine. 2021;13(576).
12. Madan E, Dimitrion P*, Peixoto ML*, et al. Cell competition boosts clonal evolution and hypoxic selection in cancer. Trends in Cell Biology. 2020;0(0).
13. Xu, Y., Dimitrion, P., Cvetkovski, S., Zhou, L., Mi, Q.S. Epidermal resident γδ T cell development and function in skin. Cell Mol Life Sci. 2020;
14. Veenstra, J., Buechler, C.R., Robinson, G., Chapman, S., Adelman, M., Tisack, A., Dimitrion, P., Todter E, Kohen L, Lim HW. Antecedent Immunosuppressive Therapy for Immune-Mediated Inflammatory Diseases in the Setting of a COVID-19 Outbreak. J Am Acad Dermatol. 2020;
15. Zierden HC*, Ortiz Ortiz JI*, Dimitrion P, et al. Characterization of an adapted murine model of intrauterine inflammation-induced preterm birth [published online ahead of print, 2019 Dec 11]. Am J Pathol. 2019;S0002-9440(19)30850-8. doi:10.1016/j.ajpath.2019.10.013
16. Date, A. A., Halpert, G., Babu, T., Ortiz, J., Kanvinde, P., Dimitrion, P., Narayan, J., Zierden H, Betageri, K., Musmanno O., Wiegand, H., Huang X., Gumber, S., Hanes, J., Ensign, L. M. “Mucus-penetrating nanosuspension enema for local treatment of inflammatory bowel disease.” Biomaterials. (2018) 185:97-105.
17. Chung, S. W., Choi, J. U., Cho, Y. S., Lee, H., Kim, H. R., Won, T. H., Dimitrion, P., Jeon O. C., Kim, W. O., Kim, S. W., Kim, I. S., Kim, S. Y., Byun, Y. “Self-Triggered Apoptosis Enzyme Prodrug Therapy (STAEPT): Enhancing targeted therapies via a recurrent bystander killing effect.” Adv. Sci. (2018) 5(7): 1800368.
18. D'Aiuto, L., Naciri, J. N., Radio, N., Clayton, D., Apodaca, G., DiMai, R., Zhi, Y., Dimitrion P., Piazza, P., Demers, M., Wood, J., Yolken, R., McNulty, J., Kinchington P. R., Bloom D. C., Nimgaonkar, V. L. "Generation of three-dimensional human neuronal cultures for modeling CNS viral infections" Stem Cell Ther Res. (2018) 9(1):134 .
19. Liu, Z., Zhou, T., Ziegler, A. C., Dimitrion, P., and Zuo, L. “Oxidative Stress in Neurodegenerative Diseases: From Molecular Mechanisms to Clinical Applications,” Oxid Med Cell Longev, (2017). 2017, 2525967
20. Dimitrion, P., Zhi, Y., Clayton, D., Apodaca, G., Wilcox, M. R., Johnson, J. W., Nimgaonkar, V., D’Aiuto, L. Generation of low-density neuronal cultures from induced pluripotent stem cells (iPSCs). Mol Neuropsychiatry. (2017) 3:28-36
21. D’Aiuto, L., Williamson, K., Dimitrion, P., McNulty, J., Zepeda-Velázquez, C., Ler, S., Piazza, P., Schurdak, M. E., Joel, W., Yolken, R. H., Kinchington, P. R., Bloom, D. C., Nimgaonkar, V. Comparison of three cell-based drug screening platforms for HSV-1 infection. Antiviral Res. (2017) 142:136-140.

* = Equal Contribution

 

Other Information

Conferences Attended:

2023
65th Annual American Society for Hematology Annual Meeting and Exposition.
Karmanos Cancer Institute Tumor Biology and Microenvironment Retreat
Symposium on Hidradenitis Suppurativa Advances
Wayne State University Annual Graduate Student Research Day
American Academy of Immunology Annual Conference
Annual HFH Research Symposium
2022
Karmanos Cancer Institute Tumor Biology and Microenvironment Retreat 2022
37th Annual National MD/PhD Conference (Symposium on Immunology)
SID Annual Meeting May
Annual HFH Research Symposium May 13, 2022.
American Academy of Immunology Annual Conference
 

 

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