Recent M.D./Ph.D. graduates

Our former M.D./Ph.D. students have gone on to successful residencies at places such as Washington University in St. Louis and Emory University. Our alumni hold prestigious jobs at NIH, the FDA, and in other leading and biotechnological institutions across the country.

Check out where our alumni are now!
 

  • Muzamil Arshad

     

     

    Education: BS Benedictine University, Physics
    Graduate Program Affiliation
    Research Interests: Development, validation and applicaton of quantitative imaging in medicine/biology
    Clinical Interests
    Advisor

    Research Publications:

    Oral Presentations:

    Poster Presentations:

    Academic and Professional Honors:

    Memberships:

    Fellowships:

    Favorite Aspects of MD PhD Program

  • Olga Astapova

    Olga Astapova

     

    Education: BS University of Michigan, Biochemistry
    Graduate Program Affiliation: Pathology
    Research Interests: Biology of reproduction
    Clinical Interests: Gynecology
    AdvisorTodd Leff, Ph.D., Pathology

    Publications:

    1. Veiga-Lopez A, Astapova OI, Aizenberg EF, Lee JS, Padmanabhan V (2009) Developmental programming: contribution of prenatal androgen and estrogen to estradiol feedback systems and periovulatory hormone dynamics in sheep. Biology of Reproduction 80(4):718-25
    2. Savabieasfahani M, Kannan K, Astapova OI, Evans NP, and Padmanabhan V (2006) Developmental programming: differential effects of prenatal exposure to bisphenol-A or methoxychlor on reproductive function. Endocrinology 147(12):5956-66

    Book Chapters:

    1. Astapova, O. and Leff, T. (2009) PPAR: A Key Regulator of Adipose Tissue Formation, Remodeling and Metabolism. in Adipose Tissue in Health and Disease. Wiley-VCH, Weinheim, Germany.

    Abstracts:

    1. Astapova OI, Bergeron J, Campeau PM, Couture P, Gagne C, Hegele RA, and Leff TA (2010) Mechanistic Studies of a Diabetes-Associated Mutation in the DNA Binding Domain of Human PPARγ. 70th Scientific Sessions of the American Diabetes Association, Orlando, FL. in press
    2. Astapova OI, Herkimer CH, Olton PO, Lee JS, Flak J, and Padmanabhan V (2006) Developmental Programming: defects in preovulatory estradiol rise and gonadotropin surge dynamics in prenatal testosterone-treated ewes are not programmed by androgenic action of testosterone. 39th Annual Meeting, Society for the Study of Reproduction. Omaha, NE. Biol Reprod Special Issue p 77 (Abstract 28)
    3. Astapova OI, Steckler T, Lee TM, Jackson LM, and Padmanabhan V (2005) Fetal programming: Advanced placentome differentiation in testosterone-treated sheep is facilitated by androgenic actions of testosterone. 38th Annual Meeting, Society for the Study of Reproduction. Quebec City, QC, Canada. Biol Reprod 70 (Suppl. 1), 209.

    Awards/Honors:
    2009 Graduate Student Research Award-WSU
    2008-2009 MD PhD Student Representative-WSU
    2007 Medical Student Research Symposium ( MD PhD), Second Place-WSU
    2006 USDA National Research Initiative Fellow

    Fellowships:
    F30 Fellowship 1F30DK083195-01A2
    National Institutes of Health
    NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
    Title: Mechanistic studies of a PPAR-gamma mutation that causes lipodystrophy & diabetes
    Issue Date: 09/04/2009

    Outside Interests: Music, books, and food

    Favorite Aspects of MD PhD Program: Very nice people and lots of support from the program administration and faculty

  • Doug Atchison

    Education: BS Michigan State University, Human Biology
    Graduate Program Affiliation: Physiology
    Research Interests: Hypertension
    Clinical Interests: Undecided
    AdvisorWilliam Beierwaltes, Physiology (Henry Ford Health Systems)

    Publications/Presentations:

    1. The Influence of extracellular and intracellular calcium on the secretion of renin. Atchison DK, Beierwaltes WH. Pflugers Arch. 2013 Jan;465(1):59-69. doi: 10.1007/s00424-012-1107-x. Epub 2012 Apr 28.
    2. Hypercalcemia reduces plasma renin via Parathyroid hormone, renal interstitial calcium, and the calcium-sensing receptor. Atchison DK, Harding P, Beierwaltes WH. Hypertension 2011 Oct: 58(4):604-610. Epub 2011 Aug 8.
    3. Acute activation of the calcium-sensing receptor inhibits plasma renin activity in vivo. Atchison DK, Ortiz-Capisano MC, Beierwaltes WH. Am J Physiol Regul Integr Comp Physiol. 2010 Oct; 299(4):R1020-6. Epub 2010 Jul 21.
    4. Parathyroid hormone stimulates juxtaglomerular cell cAMP accumulation without stimulating renin release. Atchison DK, Harding P, Cecilia Ortiz-Capisano M, Peterson EL, Beierwaltes WH. Am J Physiol Renal Phyiol. 2012 Oct 15;p 303(8):F1157-65. Epub 2012 Aug. 15.
    5. Parathyroid hormone-related protein stimulates plasma renin activity via its anorexic effects on sodium chloride intake. Atchison DK, Westrick E, Szandzik DL, Gordish KL, Beierwaltes WH. Am J Physiol Endocrinol Metab. 2012 Aug; 303(4); E457-63.
    6. Adenosine inhibits renin release from juxtaglomerular cells via an A1 Receptor TRPC-mediated pathway. Ortiz-Capisano MC, Atchison DK, Harding P, Lasley RD, Beierwalted WH. Am J Physiol Renal Physiol. 2013 Jul 24.
    7. Anandamide inhibits transport-related oxygenconsumption in the loop of Henle by activating CB1 receptors. Silva GB, Atchison DK, Juncos LI, Garcia NH. Am J Physiol Renal Physiol. 2013 Feb15;304(4):F376-81. Epub 2012 Dec 5.
    8. Calcium-Sensing Receptor Activation In Vivo Decreases Plasma Renin Activity. Atchison DK, Beierwaltes WH. FASEB J. 22:3127, D496. Experimental Biology, New Orleans, LA, 2009.
    9. Calcium-inhibitable isoforms of adenylyl cyclase are not expressed in rat parathyroid. Atchison DK, Harding P, Beierwaltes WH. FASEB J. 21(S): 40: A39, 343. Experimental Biology, Washington DC, 2007.
    10. Effects of Lead on L-Type Voltage-Gated Calcium Channel Function in Smooth Muscle Cells. Atchison D.D., Cobbett P.J., Hajela R.K., Fink G.D., Atchison W.D. Abstract published at the Annual Meeting for The Society of Toxicology. March, 2006.
    11. Effects of Activation and Inhibition of Group I Metabotropic Glutamate Receptor Subtype 1 in Methylmercury-Induced Ca2 Dysregulation in Cerebellar Granule Cells in Rats. Segarra A., Atchison D.K., Atchison W.D. Abstract published at the Annual Meeting for The Society of Toxicology. March 2006.
    12. Effects of GABA-B Receptor Activation & Inhibition on Methylmercury-induced alterations of intracellular Ca in Rat cerebellar granule neurons. D.K. Atchison, W.D. Atchison. Abstract published at the Annual Meeting for The Society of Toxicology. March, 2005.

    Posters:

    1. Calcium-inhibitable isoforms of adenylyl cyclase are not expressed in rat parathyroid. Poster presented at 2007 FASEB meeting.

    Awards:

    1. Medical Student Research Day presentations 2007 and 2008
    2. MD PhD presentation day 2007 and 2008

    Grants/Fellowships: 5 year NIH F30 Fellowship award 2009

    Outside Interests: Sanchin-Ryu, working out, food

    Favorite Aspects of the MD PhD Program: In addition to research that interested me, I wanted a place that gave a strong clinical education as well

  • Daniel Barkmeier

    Dan Berkmeier

    Education: BS Illinois Wesleyan University
    Graduate Program Affiliation: Molecular Biology & Genetics
    Research Interests: Neuroscience
    Clinical Interests: Radiology
    AdvisorJeff Loeb, M.D./Ph.D. Molecular Medicine & Genetics

     

    Publications:

    1. Barkmeier DT, Senador D, Leclercq K, Pai D, Hua J, Boutros NN, Kaminski, RM. Electrical, Molecular and Behavioral Effects of Interictal Spiking in the Rat. Neurobiology of Disease. 2012. (In press).
    2. Barkmeier DT, Shah AK, Flanagan D, Atkinson MD, Agarwal R, Fuerst DR, Jafari-Khouzani K, Loeb JA. “High inter-reviewer variability of spike detection on intracranial EEG addressed by an automated multi-channel algorithm.” Clin Neurophysiol. 2011 Oct; [Epub ahead of print].
    3. Barkmeier DT and Loeb J. “An Animal Model to Study the Clinical Significanceof Interictal Spiking”. Clinical EEG and Neuroscience. 2009 Oct;40(4):234-8.

    Abstracts:

    1. “An Animal Model of Interictal Spiking” – Society for Neuroscience, 2007
    2. “Relationship Between Interictal Spiking, Behavior, and Environment in a Rat Model” – ECNS/ISNIP Joint Conference, 2008
    3. “Interictal spiking in rat neocortex replicates the molecular and cellular changes of human neocortical epilepsy ” – American Epilepsy Society, 2008
    4. “Interictal Spikes as a Model for Epileptogenesis and Psychiatric Disorders” – Neuroscience 2009

    Awards/Honors:

    1. Second Place – Poster Competition at ECNS/ISNIP Conference in Frankfurt, Germany, 2008
    2. Best Oral Presentation – Graduate Student Research Day, 2008
    3. Best poster – CMMG Retreat Poster Session, 2007
    4. Best presentation in session and second overall – Medical Student Research Symposium, 2007
    5. MD PhD Preclinical Excellence Award, 2006

    Fellowships:
    F30 Grant-“Translating human gene expression profiles of interictal spiking into a rat model”
    Epilepsy Foundation Predoctoral Fellowship 2008

    Outside Interests: Computer nerd stuff, Tae kwon Do, bowling, unusual movies and music

    Favorite Aspects of MD PhD Program: Constant integration of the clinical and research sides of education

  • Thomas Beaumont

    Education: BS Biochemistry, Wayne State University, Detroit, MI
    Graduate Program Affiliation: Center for Molecular Medicine & Genetics
    Research Interests: Neocortical epileptogenesis, Central synaptogenesis and synaptic plasticity, High-throughput approaches to genome and proteome analysis, Statistical analysis of microarray data, bioinformatics.
    Clinical Interests: Neurosurgery, Neuro-oncology: pathology and treatment of CNS tumors, Neuroradiology & functional imaging
    AdvisorJeffrey Loeb, M.D./Ph.D. Molecular Medicine & Genetics, Neurology

     

    Publications/Presentations:

    1. Beaumont TL and Loeb JA: Accumulation of PSD-95 in synaptic spines of human epileptic neocortex. 2008 (manuscript in preparation).
    2. Beaumont TL, Barkmeier DT, Yao B, Shah AK, Loeb JA: The human epileptic transcriptome reveals focal regions of CREB target gene induction. 2008 (manuscript submitted).
    3. Beaumont T, Kupsky WJ, Barger GR, and Sloan AE: Gliosarcoma with Multiple Extracranial Metastases: Case Report and Review of the Literature. j. Neurooncol 83(1):39-46, 2007.
    4. Rakhade SN, Yao B, Ahmed S, Beaumont T, Shah A, Draghici S, Krauss R, Chugani HT, Sood S, Loeb JA, A common pattern of persistent gene activation in human neocortical epileptic foci,. Ann Neurol 58:736-47, 2005.
    5. Dore-Duffy P, Balabanov R, Beaumont T, Katar M, The CNS Pericyte Response to Low Oxygen: Early Synthesis of Cyclopentatnone Prostaglandin of the J-Series. MicrovascRes 69:79-88, 2005.
    6. Balabanov R, Lisak D, Beaumont T, Lisak RP, and Dore-Duffy P: Expression of urokinase plasminogen activator receptor on monocytes from patients with relapsing-remitting multiple sclerosis: effect of glatiramer acetate (copolymer 1). Clin Diagn Lab Immunol 8:1196-1203, 2011.
    7. Dore-Duffy P, Owen C, Balabanov R, Murphy S, Beaumont T, and Rafols JA: Pericyte migration from the vascular wall in response to traumatic brain injury. Microvasc Res 60:55-69, 2000.
    8. Balabanov R, Beaumont T, and Dore-Duffy P: Role of central nervous system microvascular pericytes in activation of antigen-primed splenic T-lymphocytes. J Neurosci Re 55:578-587, 1999.
    9. Dore-Duffy P, Balabanov R, Beaumont T, Hritz MA, Harik SI, and LaManna JC: Endothelial activation following prolonged hypobaric hypoxia. Microvasc Res 57:75-85, 1999.

    Abstracts:

    1. Beaumont TL and Loeb JA: Persistent changes in PSD-95 expression, palmitoylation and synaptic targeting characterize human epileptic neocortex. 2007 Society for Neuroscience, San Diego, CA
    2. Beaumont TL, Yao B, Rakhade SN, Shah A, Loeb JA: Persistent regional induction of CREB target genes in human epileptic neocortex revealed by transcriptome analysis. Curing Epilepsy 2007, NIH/NINDS, Bethesda, MD
    3. Beaumont TL, Rakhade SN, Ahned S, Yao B, Shah A, Loeb JA: Genome-wide transcriptional analysis of human epileptic neocortex implicates modulators of synaptic potentiation. Gordon Research Conference, 2006, Colby College, Waterville, ME
    4. Beaumont TL, Yao B, Ahmed S, Suwa K, Asano E, Shah A, Loeb JA: Activity-dependent gene expression profiles in human neocortical epilepsy implicate modulaors of glutamatergic synaptic strenght, 2005. Society for Neuroscience, Washington, DC
    5. Beaumont, T and Sloan, AE: Molecular Classification of Malignant Gliomas: Distinct Subtypes Identified by Gene Expression Profiling, 2003. Wayne State University, School of Medicine Research Symposium
    6. McCollom, B., Beaumont, T., Sloan, AE., Kupsky, W. Gliosarcoma with Multiple Extracranial Metastases, 2002. American Association of Neurological Surgeons
    7. Dore-Duffy P., Beaumont, T. and Sloan, AE: Central Nervous System Microvascular Pericyte Production of VEGF in Human Glioblastoma. Ann Neurol 48(3):248, 2000
    8. Dore-Duffy P, Balabanov R, Beaumont T: Functional differentiation of central nervous system microvascular pericytes in response T1-weighted and T2-weighted cytokines. ANN NEUROL 44(3): T199, 1998
    9. Dore-Duffy, P., Beaumont, T. and Bullock, R. Increased Fibrinogenic Cytokines in Traumatic Brain Injury. Journal of Neurotrauma. 14(10):A39, 1997

    Grants/Felloships/Awards:
    NIH Ruth L.Kirschstein National Research Service Award
    Sandberg Prize for Excellence in Biomedical Research, 2003

    Outside Interests: Mountaineering and ice climbing, sailing, literature, film, cooking and wine

    Favorite Aspects of WSU’s MD PhD Program: Super flexible, many MD PhD faculty with strength in clinical and basic neuroscience

    Tom has also received an individual NIH training award (the F30 – Ruth L. Kirschstein National Research Service Award, funded through NIH/NINDS, for four years for his research project titled “Activity-Dependent Gene Expression in Epileptogenesis.” In this study, Tom will use subdural recording electrodes to map human neocortical epileptic foci in patients with medically intractable seizures, and measure differential gene espression at these foci and at regions of early seizure spread using oligonucleotide microarrays. The expression level of key plasticity-associated genes will be confirmed and their cellular localization determined. Understanding activity-dependent gene expression and the cell types involved will provide new insights into human epileptogenesis that will aid in clinical management and offer new therapeutic avenues for patients with epilepsy.

  • David Bissig

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    Education: BS University of Michigan-Ann Arbor, Psychology & Philosophy
    Graduate Program Affiliation: Anatomy & Cell Biology
    Research Interests:Artificial Vision
    Clinical Interests: Neurology
    AdvisorBruce Berkowitz, PhD, Anatomy & Cell Biology

     


    Publications:

    1. Berkowitz BA, Bissig D, Dutczak O, Corbett S, North R, Roberts R. MRI biomarkers for evaluation of treatment efficacy in preclinical diabetic retinopathy. Expert Opin Med Diagn. 2013 Jul;7(4):393-403. Epub 2013 Jun 21.
    2. Bissig D, Goebel D, Berkowitz BA. Diminished Vision in Healthy Aging is Associated with Increased Retinal L-type Voltage Gated Calcium Channel Ion Influx. PLoS One. 2013;8(2):e56340. Epub 2013 Feb 14.
    3. Bissig D, Berkowitz BA. Light-dependent changes in outer retinal water diffusion in rats in vivo. Mol Vis. 2012;18:2561-xxx. Epub 2012 Oct 19.
    4. Chui TY, Bissig D, Berkowitz BA, Akula JD. Refractive Development in the “ROP Rat”. J Ophthalmol. 2012;2012:956705. Epub 2012 Feb 8.
    5. Li X, McClellan ME, Tanito M, Garteiser P, Towner R, Bissig D, Berkowitz BA, Fliesler SJ, Woodruff ML, Fain GL, Birch DG, Khan MS, Ash JD, Elliott MH. Loss of caveolin-1 impairs retinal function due to disturbance of subretinal microenvironment. J Biol Chem. 2012 May 11;287(20):16424-34. Epub 2012 Mar 26.
    6. Braun RD, Bissig D, North R, Vistisen KS, Berkowitz BA. Human tumor cell proliferation evaluated using manganese-enhance MRI. PLoS One. 2012;7(2):e30572. Epub 2012 Feb 17.
    7. Berkowitz BA, Bissig D, Patel P, Bhatia A, Roberts R. Acute systemic 11-cis-retinal intervention improves abnormal outer retinal ion channel closure in diabetic mice. Mol Vis. 2012;18:372-6. Epub 2012 Feb 7.
    8. Berkowitz BA, Bissig D, Ye Y, Valsadia P, Kern TS, Roberts R. Evidence for diffuse central retinal edema in vivo in diabetic male Sprague Dawley rats. PLoS One. 2012;7(1):e29619. Epub 2012 Jan 11.
    9. Bissig D, Berkowitz B.A. Same-session functional assessment of rat retina and brain with manganese-enhanced MRI. NeuroImage. 2011; 58(3):749-60.
    10. Berkowitz B.A., Bissig D., Bergman D., Bercea E., Kastur V.K., Roberts R. Intraretinal calcium channels and retinal morbidity in experimental retinopathy of prematurity. Mol Vis. 2011; 17:2516-26. PMCID: PMC3185031.
    11. Holt A.G., Bissig D., Mirza N., Rajah G., Berkowitz B.A. Evidence of key tinnitus-related brain regions documented by a unique combination of manganese-enhanced MRI and acoustic startle reflex testing. PLoS One. 2010; 5(12):e14260. PMIC: PMC3002264.
    12. Berkowitz B.A., Roberts R., Bissig D. Light-dependant intraretinal ion regulation by melanopsin in young awake and free moving mice evaluated with manganese-enhanced MRI. Mol Vis. 2010; 16:1776-80. PMCID: PMC2929942.
    13. Ivanova E., Roberts R., Bissig D., Pan Z-H., Berkowitz B.A. Retinal channelrhodopsin-2-mediated activity in vivo evaluated with manganese-enhanced magnetic resonance imaging.
    14. Berkowitz B.A., Gradianu M., Bissig D., Kern T.S., Roberts R., 2009. Retinal ion regulation in a mouse model of diabetic retinopathy: Natural history and the effect of Cu/Zn superoxide dismutase overexpression. Investigative Ophthalmology & Visual Science, 50(5), 2351-2358. PMCID: PMC2688071
    15. Berkowitz B.A., Roberts R., Oleske D.A., Chang M., Schafer S., Bissig D., Gradianu M., 2009. Quantitative mapping of ion channel regulation by visual cycle activity in rodent photoreceptors in vivo, Investigative Ophthalmology & Visual Science, 50(4), 1880-1885. PMCID: PMC2696261
    16. Bissig D., Berkowitz B.A., 2009. Manganese-enhanced MRI of layer-specific activity in the visual cortex from awake and free-moving rats. NeuroImage, 44(3), 627-637. PMCID: PMC2642584
    17. Berkowitz B.A., Roberts R., Luan H., Bissig D., Bui B.V., Gradianu M., Vingrys A.J., 2007. Manganese-enhanced MRI studies of alterations of intraretinal ion demand in models of ocular injury, Investigative Ophthalmology & Visual Science 48(8): 3796-3804. PMCID: PMC2041849
    18. Bissig D., Lustig C. 2007. Who benefits from memory training? Psychological Science, 18(8): 720-726

    Abstracts:

    1. Bissig, D., Berkowitz,B., (October, 2009). Manganese-enhanced MRI of retinal and central visual system activity in the rat. Abstract for poster presentation, Society for Neuroscience Annual Meeting, Chicago, Il.
    2. Berkowitz, B.A., Roberts,R., Luan,H., Bissig,D., Bui,B.V., Vingrys,A.J., Gradianu,M., (May 2007). Manganese-enhanced MRI studies of intraretinal dyshomeostasis. Abstract for poster presentation, The Association for Research in Vision and Opthalmology Annual Meeting, Fort Lauderdale, FL.
    3. Askren, M., Bissig,D., Lustig,C., (May, 2007). Do breakdowns in interhemispheric processing contribute to age differences in emotion recognition? Abstract for poster presentation, Cognitive Neuroscience Society Annual Meeting, New York, NY.
    4. Bissig, D., Walsh,M., Reinink,A., Lustig,C., (April 2006). Who benefits from memory training? Impact of individual differences in strategy use. Abstract for poster presentation, Cognitive Aging Conference, Atlanta, GA.

    Awards/Honors:

    1. Reviewer for Behavioral Brain Research, 2010
    2. NeuroImage Editor’s Choice Award (for Bissig & Berkowitz, NeuroImage, 44(3), 627-637), 2009
    3. Board of Governors Medical Scholarship, Wayne State University, 2006-2008

    Professional Memberships/Societies:
    Membership in the American Medical Association, 2006-present
    Membership in the Michigan Chapter of the Society for Neuroscience, 2009
    Membership in the Society for Neuroscience, 2009

    Fellowships:
    F30 Grant
    National Institute of Aging
    Score: 10
    Submission December 2009

    Outside Interests: Reading, Painting

    Favorite Aspects of MD PhD Program:

  • Alyssa Bottrell

    Alyssa Bottrell

    Education: BS, Oakland University, Biochemistry
    Graduate Program Affiliation: Pathology
    Research Interests: Breast Cancer
    Clinical Interests: Medical Oncology
    AdvisorHyeong-Reh Kim, Ph.D., Pathology

    Publications/Presentations:

    1. Goldberg AF, Ritter LM, Khattree N, Peachy NS, Fariss RN, Dang L, Yu M, Bottrell AR. 2007. An intramembrane glutamic acid governs peripherin/rds function from photoreceptor disk morphogenesis. Invest Ophthalmol Vis Sci. 48(7):2975-86.
    2. “Soluable expression of the EC2 domain of peripherin/rds.” Poster presentation. Center for Biomedical Research’s Biomedical Research Forum.
    3. “Alternative fuels and making school chemistry laboratories “greener.” Poster presentation and demonstration. Green Chemistry Symposium.

    Abstracts:

    1. Bottrell, AR, Raju, U, Lu, M, Kapke, A, Wolman, SR, Worsham, MJ. 2007. Risk Factors for Breast Cancer from Benign Breast Disease in a Diverse Population. Abstract for poster presentation at the American Association for Cancer Research the Science of Cancer Health Disparities Meeting, Atlanta, GA, November 27th-30th, 2007.
    2. Bottrell, AR, Raju, U, Kapke, A, Lu, M, Wolman, SR, Worsham, MJ. Abstract (accepted), American Association for Cancer Research Annual Meeting 2008, San Diego, CA, April 2008.

    Awards:

    1. American Association for Cancer Research-AstraZeneca Scholar-in-Training Travel Award to attend the November 2007 AACR Science of Cancer Health Disparities Meeting, Atlanta, GA.
    2. American Assocation for Cancer Research-Aflac Scholar-in-Training Travel award to attend the April 2008 AACR Annual Meeting, San Diego, CA.

    Outside Interests: My beautiful baby. I love movies, traveling and food. I like to cook, but I haven’t figured out if I’m any good at it yet. I also volunteer for the Michigan Humane Society training the shelter dogs and helping with annual telethon/adoptathon.

    Favorite Aspects of MD PhD Program:

  • Erik Brown

    Education: BS Electrical Engineering, University of Michigan, Ann Arbor
    Graduate Program Affiliation: Translational Neuroscience Program
    Research Interests: EEG/ECoG, Epilepsy, Functional Brain Mapping, Biomedical Engineering, Neuroimaging
    Clinical Interests: Neurology, Neurosurgery, Epilepsy, Helping the Uninsured
    AdvisorEishi Asano, MD, PhD – Pediatrics, Neurology, Electrophysiology (Children’s Hospital of Michigan)

    Publications:

    1. Evaluating Signal-Correlated Noise as a Control Task with Language-Related Gamma Activity on Electrocorticography. Clinical Neurophysiology; (in press).
    2. Brown EC, Jeong JW, Muzik O, Rothermel R, Matsuzaki N, Juhasz C, Sood S, Asano E. Evaluating the Arcuate Fasciculus with Combined Diffusion-Weighted MRI Tractography and Electrocorticography. Hum Brain Mapp. 2013 Aug 24.
    3. Brown EC, Matsuzaki N, Asano E. The Transient Effect of Interictal Spikes from a Fontal Focus on Language-Related Gamma Activity. J Epilepsy and Behavior. 2012 Aug; 24(4):497-502.
    4. Brown EC, Muzik O, Rothermel R, Matsuzaki N, Asano E. Evaluating Reverse Speech as a Control Task with Language-Related Gamma Activity on Electrocorticography. Neuroimage. 2012 May 1;60(4):2335-45.
    5. Brown EC, Rothermel R, Nishida M, Juhasz C, Muzik O, Hoechstetter K, Sood S, Chugani HT, Asano E. In vivo animation of auditory-language-induced gamma-oscillations in children with intractable focal epilepsy. NeuroImage, 2008; 41:1120-31. (Animation movie can be found here: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2424169/bin/NIHMS47354-supplement-Video_S1.mpg).

    Oral Presentations:

    1. Mathur A, Yin J, Brown EC, Grimm M, Leff T, Sokol R. Research Training: What You Get May Not Necessarily Be What You Need or Want. Panel discussion as part of the Professional and Academic Development Seminar, Wayne State University, Detroit, MI, December 2009.
    2. Brown EC, Asano E, Rothermel R, Nishida M, Juhasz C, Muzik O, Sood S, Chugani HT. In-vivo animation of auditory-language-evoked gamma-oscillations in children with intractable focal epilepsy. Oral presentation at Wayne State University School of Medicine’s Medical Student Research Symposium, Detroit, MI, January 2008.

    Poster Presentations:

    1. Brown EC, Muzik O, Rothermel R, Nagasawa T, Juhasz C, Sood S, Asano E. A probability map of naming based upon event-related electrocorticography. For the poster session hosted by the American Society for Clinical Investigation and the Association of American Physicians Joint Meeting at the Sixth Annual Meeting of the American Physician Scientists Association, Chicago, IL, April 2010.
    2. Brown EC, Asano E. Brain waves and their utility in pre-surgical pediatric brain mapping. Wayne State University’s Graduate Exhibition, Detroit, MI, March 2010.
    3. Brown EC, Rothermel R, Nagasawa T, Juhasz C, Sood S, Asano E. In vivo cortical mapping of the right hemisphere via auditory-language-related gamma-oscillations in children with intractable focal epilepsy. Wayne State University School of Medicine’s Graduate Student Research Day, Detroit, MI, September 2009.
    4. Brown EC, Loeb JA, Barkmeier D, Balan K, Beaumont T, Rakhade S. Identification of new molecular targets for human epilepsy. National MD PhD Conference, Keystone, CO, July 2009.
    5. Brown EC, Loeb JA, Barkmeier D, Balan K, Beaumont T, Rakhade S. Identification of new molecular targets for human epilepsy. Wayne State University School of Medicine’s Medical Student Research Symposium, Detroit, MI, January 2009.
    6. Brown EC, Loeb JA, Barkmeier D, Balan K, Beaumont T, Rakhade S. Identification of new molecular targets for human epilepsy. In the Neurobiology/Neuroscience category of the AMA Medical Student Section and AMA Resident and Fellow Section Joint Research Poster Symposium, Orlando, FL, October 2008.
    7. Brown EC, Loeb JA, Barkmeier D, Balan K, Beaumont T, Rakhade S. Identification of new molecular targets for human epilepsy. Wayne State University School of Medicine’s MD PhD Student Research Day, Detroit, MI, October 2008.
    8. Brown EC, Asano E, Rothermel R, Nishida M, Juhasz C, Muzik O, Sood S, Chugani HT. In-vivo animation of auditory-language-evoked gamma-oscillations in children with intractable focal epilepsy. The 61st Annual Meeting of the American Epilepsy Society, Philadelphia, PA, November/December 2007.
    9. Brown EC, Asano E, Rothermel R, Nishida M, Juhasz C, Muzik O, Sood S, Chugani HT. In-vivo animation of auditory-language-evoked gamma-oscillations in children with intractable focal epilepsy. Wayne State University School of Medicine’s MD PhD Student Research Day, Detroit, MI, November 2007.

    Awards:

    1. 2012 Asselin Award, Department of Psychiatry & Behavorial Neurosciences, for First-Authored Paper.
    2. Third Place, Graduate Exhibition. Wayne State University, 2011.
    3. First Place for Oral Presentation, Graduate Student Research Day. Wayne State University School of Medicine, 2010.
    4. Excellence in Research Award. State-wide graduate student research publication competition organized by the Blue Cross Blue Shield of Michigan, 2009.
    5. Outstanding Graduate/Professional Student Award. Honored at the Campus Life Leadership Awards Ceremony, Wayne State University, Detroit, MI, 2009.
    6. Neurobiology/Neuroscience Category First Place Winner. AMA Medical Student Section and AMA Resident and Fellow Section Joint Research Poster Symposium, Orlando, FL, October 2008.
    7. First Place for MD PhD Competition. Wayne State University School of Medicine’s Medical Student Research Symposium, Detroit, MI, January 2008.
    8. Lois and Herschel Sandberg Award for Biomedical Research. Wayne State University School of Medicine’s Medical Student Research Symposium, Detroit, MI, January 2008.

    Outside Interests: Ice Hockey, Skateboarding, Snowboarding, Surfing, Guitar, Singing, Marathons, Triathlons, Spanish, and Traveling.

  • John Timothy Caldwell Jr.

    Education: BS with Honors Michigan State University, Human Physiology, Biochemistry and Molecular Biology
    Graduate Program Affiliation: Oncology
    Research Interests: Molecular & Cellular Biology
    Clinical Interests: Internal Medicine
    AdvisorJeffrey Taub, M.D., Oncology

    Outside Interests: Climbing, Camping, Hiking, spending time with friends and family
     

  • Stephen Dzul

    Image result for stephen dzul

    Education: B.S.E in Chemical Engineering, University of Michigan-Ann Arbor
    Graduate Program Affiliation: Biochemistry and Molecular Biology
    Research Interests: FeS-Cluster Biogenesis via the Eukaryotic FeS-Cluster pathway (ISC), Biophysical characterization of metal-binding sites in metalloproteins.
    Advisor: Timothy Stemmler, Ph.D.

    Publications/Presentations:

    1. Blahut, M.; Dzul, S.; Wang, S.;Kandegedara, A.; Grossoehmec, N.; Stemmler, T.; Outten, FW. Conserved cysteine residues are necessary for nickel-induced allosteric regulation of the metalloregulatory protein YqjI (NfeR) in E. coli. J Inorg Biochem. 2018; 184: 123-133.

    2. Truong, P.; Gale, E.; Dzul, S. P.; Stemmler, T. L.; Harrop, T. C., Steric Enforcement About One Thiolate Donor Leads to New Oxidation Chemistry in NiSOD. J Inorg Chem. 2017;  56(14): 7761-7780.

    3. Steiner, R. A.; Dzul, S. P.; Stemmler, T. L.; Harrop T. C., Synthesis and Speciation-Dependent Properties or a Multimetallic Model Complex of NiSOD That Exhibits Unique Hydrogen-Bonding. J Inorg Chem. 2017; 56(5): 2849-2862.

    4. Dzul, S. P.; Rocha A. G.; Rawat, S.; Kandegadara, A.; Kusowski, A.; Pain, J.; Murari, A.; Pain, D.; Dancis, A.; Stemmler, T. L., In vitro characterization of a novel Isu homologue from D. Melanogaster for de novo FeS-cluster formation. Metallomics. 2016; 9(1): 48-60.

    5. Walter, M. R.; Dzul, S. P.; Rodrigues, A. V.; Stemmler, T. L.; Telser, J.; Conradie, J.; Ghosh A.; Harrop, T. C., Synthesis of Co-NO complexes and their reactivity as a source of hydroxyl. J Biol Chem. 2016; 138: 12459-12471.

    6. Dzul, S. P.; Barupala, D. P.; Riggs-Gelasco, P. J.; Stemmler, T. L., Synthesis, delivery and regulation of eukaryotic heme and Fe-S cluster cofactors. Arch Biochem Biophys. 2016; 592: 60-75.

    7. Dzul, S. P.; Stemmler, T. L.; Penner-Hahn, J.E. “Manganese Proteins with Mono- and Dinuclear Metal Sites”. Encyclopedia of Inorganic and Bioinorganic Chemistry, Robert A. Scott Eds., Chichester, UK: John Wiley & Sons, Ltd., 2015.

    8. Bafaro, E. M.; Antala, S.; Nguyen, T. V.; Dzul, S. P.; Doyon, B.; Stemmler, T. L.; Dempski, R. E., The large intracellular loop of hZIP4 is an intrinsically disordered zinc binding domain. Metallomics. 2015; 7: 1319-1330.

    9. Plegaria, J. S.; Dzul, S. P.; Zuiderweg, E. R.; Stemmler, T. L.; Pecoraro, V. L., Apoprotein Structure and Metal Binding Characterization of a de Novo Designed Peptide, alpha3DIV, that Sequesters Toxic Heavy Metals. Biochemistry. 2015; 54: 2858-2873.

    10. Byrne, E.; Dzul, S.; Solomon, M.; Younger, J.; Bortz, D. M., Postfragmentation density function for bacterial aggregates in laminar flow. Phys Rev E Stat Nonlin Soft Matter Phys. 2011; 83: 041905.

    11. Dzul, S. P.; Thornton, M. M.; Hohne, D. N.; Stewart, E. J.; Shah, A. A.; Bortz, D. M.; Solomon, M. J.; Younger, J. G., Contribution of the Klebsiella pneumoniae capsule to bacterial aggregate and biofilm microstructures. Appl Environ Microbiol. 2011; 77: 1777-1782.

    Awards:
    Dorothy and Charles Pokriefka Scholarship. 2018.
    Best Oral Presentation. First place. MD/PhD Research Day. 2016.
    Best Oral Presentation: Second place. Biochemistry Research Forum. 2015.
    Outstanding Achievement. Medical Student Recognition Day. 2014.
    Thomas Rumble University Graduate Fellowship. 2012.
    Henry Ford Health Systems Student Medical Scholarship. 2011.

    Funding: 
    2014-2018 National Institute of Health: 1F30DK101230-01A1 Dzul (PI) Characterizing Isu Scaffolding Protein and ISC Multiprotein Complex. Total award: $179,000.

    2013-2014 American Heart Association: 13PRE16490009 Dzul (PI) Characterizing Isu Scaffolding Protein and ISC Multiprotein Complex. Total award: $52,000.

    Residency Match: Radiation Oncology, Detroit Medical Center, Wayne State University

  • Josh Dilworth

    Joshua T Dilworth

    Education: BS Microbiology, University of Michigan, Ann Arbor
    Graduate Program Affiliation: Pharmacology
    Research Interests: Neurofibromatosis Type1, Schwann cell biology, Cell signaling pathways in cancer development and as pharmacologic targets
    Clinical Interests: Oncology, Pathology
    Advisor:Raymond R. Mattingly, Ph.D.

    Publications/Presentations:

    1. “Primary leptomeningeal melanoma in a twenty-month-old: a case study and literature review,” Dilworth JT, Kupsky WJ, Becker CJ, Rabah RM, Poulik JM; J of Pediatric and Develop Pathology. 2008. Manuscript in preparation
    2. “Targeting ErbB receptor signaling in NF1 malignant peripheral nerve sheath tumor lines,” Dilworth JT, Hancock C, Kraniak JA, Mathieu P, Reiners JJ, Tainsky MA, Mattingly RR. J of Molec Cancer Therap. 2008. Manuscript submitted
    3. “Molecular targets for emerging anti-tumor therapies for neurofibromatosis type 1,” Dilworth JT, Kraniak JM, Wojtkowiak JW, Gibbs RA, Borch RF, Tainsky MA, Reiners JJ Jr, Mattingly RR. Biochem Pharmacol. 2006 Nov 30;72(11):1485-92. Epub 2006 Apr 28. Review. PMID: 16797490
    4. “The mitogen-activated protein kinase/extracellular signal-regulated kinase kinase inhibitor PD184352 (CI-1040) selectively induces apoptosis in malignant schwannoma cell lines,” Mattingly RR, Kraniak JM,
      Dilworth JT, Mathieu P, Bealmear B, Nowak JE, Benjamins JA, Tainsky MA, Reiners JJ. J Pharmacol Exp Ther 2006 Jan;316 (1):456-65.PMID: 16239399

    Abstracts:

    1. “Adaptive image-guided radiotherapy (IGRT) eliminates the risk of geometric miss due to rectal distention in prostate cancer treatment planning: biochemical and clinical evidence of efficacy,” McGrath S, Kestin L, Dilworth JT, Liang J, Krauss D, Yan D, Vicini F, Martinez A; American Society of Therapeutic Radiology and Oncology (‘08)
    2. “Superior mesenteric artery syndrome: clinical presentation, diagnosis, and treatment Strategies,” Shah R, Dilworth JT, Shanti C; Frederick A. Coller Surgical Society Meeting (Sep ’07)
    3. “Deregulated N-Ras increases EGFR expression and activity in neurofibromatosis type 1 (NF1) MPNST cells,” Dilworth JT, Kraniak JM, Reiners JJ, Tainsky MA, Mattingly RR; Gordon Research Conference: Mechanisms of Cell Signaling, Hong Kong, China (Jun ’05)
    4. “The EGFR:Ras axis in NF1 Malignant Peripheral Nerve Sheath Tumor Lines,” Dilworth JT, Kraniak JM, Tainsky MA, Reiners JJ, Mattingly RR; American Association for Cancer Research: Karmanos Cancer Institute, Detroit, MI (Jul ’05)
    5. “Deregulated N-Ras increases EGFR expression and activity in neurofibromatosis type 1 (NF1) MPNST cells,” Dilworth JT, Kraniak JM, Reiners JJ, Tainsky MA, Mattingly RR; Federation of American Societies for Experimental Biology Conference, San Diego, CA (Apr ’05)
    6. “The mitogen-activated protein kinase/extracellular signal-regulated kinase kinase inhibitor PD184352 (CI-1040) selectively induces apoptosis in malignant schwannoma cell lines,” Mattingly RR, Kraniak JM, Dilworth JT, Mathieu P, Bealmear B, Nowak JE, Benjamins JA, Tainsky MA, Reiners JJ; 12th International Conference on Second Messengers and Phosphoproteins, Montreal, QC, Canada (Aug ’04)

    Awards:

    • Frank B. Walker, M.D. Endowed Memorial Prize-recognizing academic achievement and leadership in the study of scientific research (Mar ’08)
    • Distinction in Biomedical Research award 2008
    • Clinical Honors: Obstetrics and Gynecology, Pediatrics, Family Medicine, Emergency Medicine, Pediatric Surgery, Internal Medicine, Radiation Oncology (’06-’07)
    • Cumulative Graduate School GPA: 4.0/4.0 (’00-’05)
    • Three Travel Awards, Department of Pharmacology (Jun and Apr ’05, Aug ‘04)
    • Exceptional Academic and Research Accomplishment Award (Nov ’04)
    • 1st Place, oral presentation: Graduate Student Research Day (Sep ’04)
    • Competitive Award for Academic Excellence (Oct ’03)
    • Featured interview in the W.S.U. publication “Scribe,” highlighting community out-reach program (D.O.C.S.)

    Grants/Fellowships: n/a

    Outside Interests: Music, Sign Language, Volleyball, Teaching

    Favorite aspects of MD PhD program: Discovery, autonomy, variety

  • Jessin John

    Education: BS Electrical/Computer Engineering, Wayne State University, Detroit, MI
    Graduate Program Affiliation: Electrical and Computer Engineering
    Research Interests: MEMS and NanBioScience
    Clinical Interests: Neuroscience/Neurosurgery
    Advisor: Yong Xu, Ph.D., Electrical and Computer Engineering
    Outside Interests: Music Minister at International Assembly of God (Warren, MI), Bass Guitarist (Michigan Beats), Tae Kwon Do

  • Eric Kim

    Education: B.E. in Biomedical Engineering, Vanderbilt University
    Graduate Program Affiliation: Biomedical Engineering
    Research Interests: Medical technology, particularly medical microtechnology including point-of-care sensors, mobile medicine, and bioelectrical interfaces
    Advisor: Yong Xu, Ph.D., Electrical and Computer Engineering

    Publications/Presentations:

    Kim EGR. Multiple doctors, different recommendations for multiloculated pyogenic hepatic abscesses. Clin. Res. Prac. 2018;4(1):eP1404. doi: 10.22237/crp/1518739320.

    Ahsan SF, Luo H, Zhang J, Kim E, Xu Y. An animal model of deep brain stimulation for treating tinnitus: A proof of concept study. The Laryngoscope. 2018;128(5):1213-22. Epub 2017/09/20. doi: 10.1002/lary.26876. PubMed PMID: 28925013.

    Zhao Z, Kim E, Luo H, Zhang J, Xu Y. Flexible deep brain neural probes based on a parylene tube structure. Journal of Micromechanics and Microengineering. 2018;28(1):015012.

    Liu B, Kim E, Meggo A, Gandhi S, Luo H, Kallakuri S, Xu Y, and Zhang J. Enhanced biocompatibility of neural probes by integrating microstructures and delivering anti-inflammatory agents via microfluidic channels. Journal of Neural Engineering. 2017, Apr; 14(2): 1741-2552. Cited in PubMed; PMID: 28155844.

    Zhao Z, Tu H, Kim EGR, Sloane BF, Xu Y,. A flexible Ag/AgCl micro reference electrode based on a parylene tube structure. Sensors and Actuators B: Chemical. 2017, Feb; 247(n/a): 92-97.

    Kim EG, Tu H, Luo H, Liu B, Bao S, Zhang J, Xu Y. 3D silicon neural probe with integrated optical fibers for optogenetic modulation. Lab on a Chip. 2015, Jul; 15(14): 2939-49. Cited in PubMed; PMID: 26097907.

    Hu Y, Kim EG, Cao G, Liu S, Xu Y. Physiological acoustic sensing based on accelerometers: a survey for mobilehealthcare. Annals of biomedical engineering. 2014, Nov; 42(11): 2264-77. Cited in PubMed; PMID: 25234130.

    Byrd Iv TF, Hoang LT, Kim EG, Pfister ME, Werner EM, Arndt SE, Chamberlain JW, Hughey JJ, Nguyen BA, Schneibel EJ, Wertz LL, Whitfield JS, Wikswo JP, Seale KT. The microfluidic multitrap nanophysiometer for hematologic cancer cell characterization reveals temporal sensitivity of the calcein-AM efflux assay. Scientific Reports. 2014, May; 4(2014): 5117. Cited in PubMed; PMID: 24873950.

    Kim EGR, John JK, Tu H, Zheng Q, Loeb J, Zhang J, Xu Y. A hybrid silicon–parylene neural probe with locally flexible regions. Sensors and Actuators B: Chemical. 2014, Jan; 195(n/a): 416-22.

    Kim E, Tu H, Lv C, Jiang H, Yu H, Xu Y. A robust polymer microcable structure for flexible devices. Applied Physics Letters. 2013, Jan; 102(3): 033506.

    Harris MP, Kim E, Weidow B, Wikswo JP, Quaranta V. Migration of isogenic cell lines quantified by dynamicmultivariate analysis of single-cell motility. Cell adhesion & migration. 2009, Mar; 2(2): 127-36. Cited in PubMed; PMID: 19271355.

    Elkareh J, Kennedy DJ, Yashaswi B, Vetteth S, Shidyak A, Kim EG, Smaili S, Periyasamy SM, Hariri IM, Fedorova L, Liu J, Wu L, Kahaleh MB, Xie Z, Malhotra D, Fedorova OV, Kashkin VA, Bagrov AY, Shapiro JI. Marinobufagenin stimulates fibroblast collagen production and causes fibrosis in experimental uremic cardiomyopathy. Hypertension. 2006, Dec; 49(1): 215-24. Cited in PubMed; PMID: 17145984.

    Xu Y, Tu H, Kim EG, and John J. (2012, July 31). A novel SOI-CMOS compatible method to fabricated flexible, foldable and stretchable devices. US provisional patent No. 61/677,795

     

    Awards: 
    George Mogill, M.D. Endowed Award for Family Medicine – 2018
    Graduation with Distinction in Biomedical Research – 2018
    Clinical commendations all year 3 rotations – 2016-2017
    Honors for family medicine core rotation and family medicine elective – 2017
    Southeast Michigan Academy of Family Physicians Student Attendee Scholarship – 2017
    American Academy of Family Physicians First-time Student Attendee Scholarship – 2017
    Graduate Research Exhibition Wayne State University 2nd place poster – 2016
    Ralph H. Kummler Award for Distinguished Achievement in Graduate Student Research – 2015
    Summer Dissertation Fellowship – 2015
    WSU MD/PhD Research Day Best Presentation Award – 2014 & 2015
    Invited Panelist at the BMES 2014 Midwest Biomedical Engineering Career Conference – 2014
    Tau Beta Pi Engineering Honor Society – 2014
    Golden Key International Honor Society – 2012
    Wayne State University School of Medicine Board of Governors Scholarship MD/PhD – 2009-2017

    Conferences Attended:
    Kim EGR, Kraus C, Collins J. (May, 2017). Case Report of Streptococcus Pasteurianus Bacteremia and Septic Hip
    Arthroplasty Poster presented at: Michigan American College of Physicians Medical Student Day; Detroit, MI,
    USA.

    Kim EGR, Tu H, Luo H, Zhang J, Xu Y. (June, 2016). A MEMS Parylene Tube Rat Cochlear Implant Device with
    Microfluidics and Tunable Mechanical Properties Poster presented at: North American Neuromodulation Society;
    Baltimore, MD, USA.

    Kim EGR, Hu T, Luo H, Zhang J, Xu Y. (June, 2016). A Super Long MEMS Neural Probe for Recording Neural
    Spiking in Deep Brain Structures Poster presented at: North American Neuromodulation Society; Baltimore, MD, USA.

    Kim EGR, Tu H, Luo H, Bin L, Zhang J, Xu Y. (February, 2015). A MEMS Based Stimulating Cochlear Implant
    with Integrated Microfluidics for Drug Delivery Poster presented at: Association for Research in Otolaryngology
    Mid Winter Meeting; Baltimore, MD, USA.

    Chen M, Luo H, Kim EGR, Xu Y, Zhang J. (February, 2015). A Novel Cochlear Implant for Electrical Stimulation
    in the Rat Via a Minimally-Invasive Postauricular Approach Poster presented at: Association for Research in
    Otolaryngology Mid Winter Meeting; Baltimore, MD, USA.

    Kim EGR, John JK, Tu H, Zhang J, Xu Y. (September, 2014). A Multifunctional 3D Penetrating Silicon
    Microelectrode Array Poster presented at: 18th Annual Wayne State University School of Medicine Graduate
    Student Research Day; Detroit, MI, USA.

    Bin L, Meggo A, Kim EGR, Xu Y, Zhang J. (August, 2014). A 3D Penetrating Silicon Microelectrode Array for
    Treating Tinnitus – The Biocompatibility Study Poster presented at: 5th Anniversary Symposium on Biomechanics
    of Injury and Safety Engineering; Detroit, MI, USA.

    Kim EGR, Tu H, Liu B, Luo H, Zhang J, Xu Y. (June, 2014). Integrated Open Architecture Electrodes and Drug
    Reservoir for Improvement of Chronic Stability in 3D Penetrating Silicon Microelectrode Arrays Poster presented
    at: 41st Neural Interfaces Conference; Dallas, TX, USA.

    Kim EGR, Tu H, Luo H, Bao S, Zhang J, Xu Y. (June, 2014). Integration of Fiber-Optics and Flexible Microfluidic
    Channels for Enhancing Functional Capabilities in 3D Penetrating Silicon Microelectrode Arrays Poster presented
    at: 41st Neural Interfaces Conference; Dallas, TX, USA.

    Kim EGR, John J, Tu H, Xu Y. (November, 2013). Multifunction 3D Micro Electrode Arrays with Integrated
    Microfluidics Based on a Simple Folding Process Oral Presentation presented at: H.R. Lissner Research Day;
    Detroit, MI, USA.

    John J, Kim E, Tu H, Zhang J, Loeb J, and Xu Y. (June, 2013). Multifunctional chronic 3d electrode arrays based
    on a simple folding process Poster presented at: The 17th International Conference on Solid-State Sensors,
    Actuators and Microsystems; Barcelona, ESP.

    Kim EGR, John J, Tu H, Li Y, Xu Y. (May, 2013). Multifunction 3D Electrode Arrays Based on a Simple Folding
    Process Poster presented at: Nano and Micro Manufacturing Workshop; Dearborn, MI, USA.
    Tu H, Kim E, and Xu Y. (October, 2012). An In-Channel Micro Check Valve Fabricated Using a Simple Two-Mask
    Process Poster presented at: IEEE SENSORS 2012; Taipei, TWN.

    John J, Kim EGR, Tu H, Li Y, Loeb J, Xu Y. (September, 2012). 3D Neural Probes with Combined Electrical and
    Chemical Interfaces Poster presented at: 7th The Eye and The Chip World Research Congress; Detroit, MI, USA.
    Kim EGR, John J, Li Y, Xu Y. (June, 2012). Robust Flexible Cable Structure for Foldable 3D Neural Probes Poster
    presented at: 40th Neural Interfaces Conference; Salt Lake City, UT, USA.

    Kim EGR, Sivasubramaniam P, Wikswo JP, and Seale KT. (October, 2008). Differential Optical Flow for
    Automated Cell Motility Poster presented at: Twelfth International Conference on Miniaturized Systems for
    Chemistry and Life Sciences; San Diego, CA, USA.

    Kim E, Harris M, Weidow B, Quaranta V, Wikswo J, and Seale K. (October, 2008). Quantification Of Cellular
    Motility For Application To Biological Assays Poster presented at: Biomedical Engineering Society Annual
    Meeting; St Louis, MO, USA.

    Harris M, Kim E, Weidow B, Wikswo J, Quaranta V. (May, 2008). Dynamic Multivariate Analysis of Single Cell
    Motility Poster presented at: Institute for Mathematics and its Applications; Minneapolis, MN, USA.
    Kim EGR, Sivasubramaniam P, Wikswo J, Seale K. (September, 2007). Cytokinetic Quantification In A
    Microfluidics Device Poster presented at: Biomedical Engineering Society Annual Meeting; Los Angeles, CA, USA.

    Funding:
    GRA with Wayne State University College of Engineering
    Summer Dissertation Fellowship
    NSF Nanoengineering Certificate program GTA

    Residency Match: University of Colorado Family Medicine Residency, Denver, CO

    Favorite Aspect of the M.D./Ph.D. Program: Primary care as a specialty is highly under-represented amongst MD/PhDs.  MD/PhDs are problem solvers, and many of the problems to be solved in modern health care are in primary care.  Imagine the impact we could have, the doors we could open up, and the lives we could change for the better.

  • Lesley Lawrenson

    Education: University of California San Diego BS Biochemistry Molecular Cell Biology 2001, University of California San Diegor MS Biology “Aging Attenuates Vasodilatory Response to Isolated Small Muscle Mass Exercise” 2003
    Graduate Program Affiliation: Center for Molecular Medicine and Genetics
    Research Interests: Undecided
    Clinical Interests: Undecided
    AdvisorHenry Heng, PhD, Molecular Medicine and Genetics

    Publications/Presentations:

    1. Ye CJ, Stevens JB, Liu G, Bremer SW, Jaiswal AS, Ye KJ, Lin MF, Lawrenson L, Lancaster WD, Kurkinen M, Liao JD, Gairola CG, Shekhar MP, Narayan S, Miller FR, Heng HH. Genome based cell population heterogeneity promotes tumorigenicity: the evolutionary mechanism of cancer. J Cell Physiol 219(2):288-300, 2009.
    2. Chugani HT, Juhasz C, Chugani DC, Lawrenson L, Muzik O, Chakroborty PK, Sood S. Increased striatal serotonin synthesis following cortical resection in children with intractable epilepsy. Epilepsy Res. 78(2-3):124-30. 2008.
    3. Heng HH, Stevens JB, Lawrenson L, Liu G, Ye KJ, Bremer SW, Ye CJ. Cell Oncol. 2008;30(6):513-14.
    4. Richardson RS, Donato AJ, Uberoi A, Wray DW, Lawrenson L, Nishiyama S, Bailey DM. Am J Physiol Heart Circ Physiol 292(3):H1516-22. 2006.
    5. Donato AJ, Uberoi A, Wray DW, Nishiyama S, Lawrenson L, and Richardson RS. Differential effects of aging on limb blood flow in humans. Am J Physiol Heart Circ Physiol 290: H272-278, 2006.
    6. Wray DW, Uberoi A, Lawrenson L, and Richardson RS. Evidence of preserved endothelial function and vascular plasticity with age. Am J Physiol Heart Circ Physiol 290: H1271-1277, 2006.
    7. Wray DW, Uberoi A, Lawrenson L, and Richardson RS. vHeterogeneous limb vascular responsiveness to shear stimuli during dynamic exercise in humans. J App Physiol 99: 81-86, 2005.
    8. Bailey DM, Young IS, McEneny J, Lawrenson L, Kim J, barden J, and Richardson RS. Regulation of free radical outflow from an isolated muscle bed in exercising humans. Am J Physiol Heart Circ Physiol 287: H1689-1699, 2004.
    9. Bailey DM, Davies B, Lawrenson L, Davison GW, Isaacson R, and Richardson RS. EPR spectroscopic detection of free radical outflow from an isolated muscle bed in excercising humans. J Appl Physiol 94: 1714-1718, 2003.
    10. Barden J, Poole JG, Lawrenson L, Brown CF, Seng S, and Richardson RS. Achievement of Metabolic Limitation to Exercise in Trained Skeletal Muscle. The FASEB Journal 17: 955, 2003.
    11. Barden J, Poole JG, Lawrenson L, Brown CF, Seng S, and Richardson RS. Is Vasodilation Maximized During Maximal Small Muscle Mass Exercise?Med Sci Sports Exerc 35: 109, 2003.
    12. Lawrenson L, Hoff J, and Richardson RS. Aging Attenuates Vascular and Metabolic Plasticity but Does Not Limit Improvement in Muscle Vo2max. Am J Physiol Heart Circ Physiol, 2003.
    13. Lawrenson L, Poole JG, Kim J, Barden J, and Richardson RS. Central vs. Peripheral Limitations to Muscle VO2max in Aging Subjects. The FASEB Journal 17: 1279, 2003.
    14. Lawrenson L, Poole JG, Kim J, Barden J, and Richardson RS. The Role of Age and Activity in Vascular Responsiveness. Med Sci Sports Exerc 35: 397, 2003.
    15. Lawrenson L, Poole JG, Kim J, Brown CF, Patel PM, and Richardson RS. Vascular and Metabolic Response to Isolated Small Muscle Mass Exercise: The Effect of Age. Am J Physiol Heart Circ Physiol, 2003.
    16. Lawrenson L, Poole JG, Brown CF, Barden J, and Richarson RS. Vascular Endothelial Reactivity Mediated by {HbO2}; The Effects of Age. The FASEB Journal 16: 766, 2002.
    17. Poole JG, L. Lawrenson, J. Kim. C. Brown, J. Gonzalez-Alonzo and R. S. Richardson. Vascular Endothelial Reactivity Mediated by {HbO2}. Med, Sci, Sports, Exer 34: S32, ABSTRACT, 2002.
    18. Poole JG, Lawrenson L, Brown CF, Barden J, and Richardson RS. Leg Blood Flow During Submaximal and Maximal Large Muscle Mass Exercise in Humans. The FASEB Journal 16: 764, 2002.
    19. Poole JG, Lawrenson L, Kim J, Brown C, and Richardson RS.
    20. Poole JG, Lawrenson L, Kim J, Brown C, and Richardson RS. Vascular and metabolic response to cycle exercise in sedentary humans: effect of age. Am J Physiol 284: H1251-1259, 2003.
    21. Wagner PD, Lawrenson L, Poole JG, Gavin TP, Brown CF, and Richardson RS. Effects of Small Muscle Mass Training on Muscle Function in COPD. American Journal of Respiratory Critical Care Medicine 167: 962,. 2003.

    Grants/Fellowships: 
    National Graduate Student Research Award, American College of Sports Medicine
    Department of Defense Predoctoral Fellowship

    Outside Interests: Triathlon, hiking, camping

  • John Lillvis

    John Lillvis, MD - Pediatrics

    Education: BA Swarthmore College, Chemistry/Religion
    Graduate Program Affiliation: Center for Molecular Medicine & Genetics
    Research Interests: Genetics, Vascular Biology, Diseases of Aging
    Clinical Interests:Undecided
    Advisor: Helena Kuivaniemi/Wayne Lancaster

     

    Publications/Presentations:

    1. Lillvis JH, Erdman R, Schworer CM, Golden A, Derr K, Gatalica Z, Cox LA, Shen J, VanderHeide RS, Lenk GM, Hlavaty L, Li L, ELmore JR, Franklin DP, Gray JL, Garvin RP, Carey DJ, Lancaster WD, Tromp G, Kuivaniemi H. Regional expression of HOXA4 along the aorta and its potential role in human abdominal aortic aneurysms. BMC Physiol. 2011 May; 11:9.
    2. Lillvis JH, Kyo Y, Tromp G, Lenk GM, Li M, Lu Q, Igo RP Jr, Sakalihasan N, Ferrell RE, Schworer CM, Gatalica Z, Land S, Kuivaniemi H. BMC Med Genet. 2011 Jan; 12:14.
    3. Lillvis JH, Lanfear DE. Progress toward genetic tailoring of heart failure therapy. Curr Opin Mol Ther. 2010 June; 12(3):294-304.
    4. Boddy AM, Lenk GM, Lillvis JH, Nischan J, Kyo Y, Kuivaniemi H. Basic research studies to understand aneurysm disease. Drug New Perspect. 2008 Apr; 21(3)142-8.
    5. Szabo P, Li F, Matthew J, Lillvis J, Weksler ME. Cell Immunol. 2004 Sep-Oct; 231(1-2):158-67.
    6. Boddy AM, Lenk GM, Lillvis JH, Nischan J, Kyo Y, Kuivaniemi H. Basic research studies to understand aneurysm disease. Drug News and Perspectives (in press).
    7. Lillvis JH, Lenk GM, Kuivaniemi H, Genetics of Abdominal Aortic Aneurysms. In: Aortic Aneurysms: Pathogenesis and Treatment. Humana Press Inc., Totowa, NJ. G.
    8. Kuivaniemi H, Boddy AM, Lillvis JH, Nischan J, Lenk GM, Tromp G. Abdominal Aortic Aneurysms are deep, deadly and genetic. In: Aortic Aneurysms, New insights into an old problem. Leige University Press, Leige, Belgium. N Sakalihasan, H Kuivaniemi, and JB Michel, eds. (in press).
    9. Nischan J, Lenk JM, Boddy AM, Lillvis JH, Tromp G, Kuivaniemi H. Abdominal Aortic Aneurysms-a Complex Genetic Predisposition to Disease, Nova Science Publishers, Inc., Hauppauge, NY (in press).

    Fellowships: 
    NIH F30 Immunity and the Pathogenesis of Abdominal Aortic Aneurysms
    NIH Ruth L. Kirschstein National Research Service Award

    Outside Interests: Running, cooking, listening to music

    Favorite Aspects of the program: Combination of strong research and great clinical training

  • Christopher McHugh

    Image result for christopher mchugh wayne state university

    Education: B.S. in Biochemistry, University of Michigan-Ann Arbor
    Graduate Program Affiliation: Cancer Biology
    Research Interests: Utilizing PET imaging to monitor response to chemotherapy
    Advisor: Anthony Shields, M.D., Ph.D, Cancer Biology

    Publications/Presentations:

    McHugh CI, Thipparthi M, Polin L, Lawhorn-Crews JM, Gadgeel S, Akoury J, Patki M, Douglas KA, Mangner TJ, Li J, Matherly LH, Ratnam M, Shields AF: A translational model utilizing radiolabeled FLT with PET to monitor the effect of dexamethasone on non-small cell lung cancer. J Nucl Med. 2018 Apr 19 [Epub ahead of print]

    McHugh CI, Lawhorn-Crews JM, Douglas KA, Modi D, Jones SK, Mangner TJ, Collins JM, Shields AF: Effects of capecitabine treatment on the uptake of thymidine analogs using exploratory PET imaging agents: 18F-FAU, 18F-FMAU, and 18F-FLT. Cancer Imaging. 2016;16(1):34.

    Li J, Kim S, Shields AF, Douglas KA, McHugh CI, Lawhorn-Crews JM, Wu J, Mangner TJ, LoRusso PM: Integrating Dynamic Positron Emission Tomography and Conventional Pharmacokinetic Studies to Delineate Plasma and Tumor Pharmacokinetics of FAU, a Prodrug Bioactivated by Thymidylate Synthase. J Clin Pharmacol. 2016;56(11):1433-1447.

    McHugh CI, Shields A: FLT-PET Evaluation of Radiation Response. J Nucl Med. 2015;56(6):813-4.

     

    Awards: 
    2012 – 2013 – Prentis Foundation Medical Scholarship, Detroit, MI
    2013 – Alpha Omega Alpha Medical Honor Society Inductee
    2015 – 2016 – DeRoy Testamentary Foundation Research Fellowship
    2016 – 2018 – O. B. Weed Merit Scholarship, Detroit, MI

    Conferences Attended:
    McHugh CI, Lawhorn-Crews J, Douglas K, Modi D, Mangner T, Shields A: The Effect of Capecitabine Treatment on the Uptake of Fluoropyrimidine Tracers: FLT, FMAU, and FAU. LBAP 045, World Molecular Imaging Society Annual Congress, Seoul, South Korea, September 20, 2014

    McHugh CI, Lawhorn-Crews J, Gadgeel S, Patki M, Mangner T, Matherly LH, Ratnam M, Shields A: Utilizing 18F-FLT to Monitor the Effect of Dexamethasone on NSCLC. LBAP 074, World Molecular Imaging Society Annual Congress, Honolulu, Hawaii, September 3, 2015

     Funding: 
    2013 – 2016 Wayne State Graduate Research Assistantship, Detroit, MI
    2015 – 2016 DeRoy Testamentary Foundation Research Fellowship, Detroit, MI

    Residency Match: Otolaryngology, Harvard Medical School / Massachusetts Eye and Ear

    Other Interests: Travel, NBA basketball, Running and Classic Rock

  • Nicholas Mischel

    Education: BS Wayne State University, Biological Sciences
    Graduate Program Affiliation: Physiology
    Research Interests: Neural control of the circulation, Cardiovascular physiology, Neurophysiology, Cognitive neuroscience, High-tech equipment
    Clinical Interests: Cardiology, Internal Medicine, Neurology, Neurosurgery
    AdvisorPatrick Mueller, Ph.D. Asst. Professor of Physiology

    Abstracts:

    1. Mueller PJ and Mischel NA. Selective enhancement of glutamate-mediated pressor responses after GABAA receptor blockade in the RVLM of sedentary versus spontaneous wheel running rats. Front. Physio.3:447, 2012 November 26.
    2. Mischel NA, Mueller PJ. (In)activity dependent alterations in resting and reflex control of splanchnic sympathetic merve activity. J Appl Physiol. 2011 Oct 6. [Epub ahead of print].
    3. Mueller PJ, Mischel NA, Scislo TJ. Differential activation of adrenal, renal, and lumbar sympathetic nerves following stimulation of the rostral ventrolateral medulla of the rat. Am J Physiol Regul Integr Comp Physiol. 2011 May; 300(5):R1230-40.
    4. Nicholas A Mischel and Lori A. Pile, PhD. Physiological Aberration In SIN3-deficient Cells Of D. Melanogaster. National Conference for Undergraduate Research. Abstract and Poster, 2007
    5. Nicholas A. Mischel, Ida J. Lewellyn-Smith, Jose A. Rafols, Patrick J. Mueller. Physical inactivity dependent neuroplasticity in the rat RVLM: A link to neurogenic hypertension? Wayne State University School of Medicine Graduate Student Research Day. Abstract and Poster, 2009
    6. Nicholas Mischel, Avril G. Holt, Patrick J. Mueller. Laser capture microdissection of spinally-projecting RVLM neurons: Analysis of NMDA receptor subunit gene expression. Experimental Biology. Abstract and Poster, 2010
    7. NA Mischel, TJ Scislo, and PJ Mueller. Stimulation of rostral ventrolateral medulla produces differential activation of sympathetic nerves. FASEB Summer Conference. Abstract and Poster, 2010
    8. NA Mischel, TJ Scislo, and PJ Mueller. Stimulation of rostral ventrolateral medulla produces differential activation of sympathetic nerves. Wayne State University/University of Michigan Physiology Symposium. Abstract and Poster, 2010
    9. NA Mischel, TJ Scislo, PJ Mueller. Stimulation of rostral ventrolateral medulla produces differential activation of sympathetic nerves. Wayne State University School of Medicine Graduate Student Research Day. Abstract and Poster, 2010

    Awards & Honors:

    • 2007 Phi Beta Kappa National Honor Society
    • 2007 Magna Cum Laude
    • 2009-2010 American Heart Association Predoctoral Fellowship, Project title: “NMDA Receptor Neuroplasticity in the RVLM Following Imposition of Sedentary Conditions”
    • 2010-Present NIH F30 Enhanced Sympathoexcitation and Inactivity: Role of NMDA Neuroplasticity in RVLM
    • 2010 Graduate Professional Scholarship winner
    • 2010 Best Poster Award-Wayne State University/University of Michigan Physiology Symposium
    • 2010 Invited Speaker-Wayne State University/University of Michigan Physiology Symposium

    Fellowships:
    2010-Present NIH F30 Enhanced Sympathoexcitation and Inactivity: Role of NMDA Neuroplasticity in RVLM
    2009-American Heart Association Predoctoral Fellowship

    Outside Interests: Singing with the Ultrasounds and UMS Choral Union, playing guitar, tennis, Michigan State Spartans Basketball, eating out in Detroit with my girlfriend, visiting family (Especially my little niece Lillian Rose)

  • Levent Sipahi

    Education: BS, Kalamazoo College, Biology
    Graduate Program Affiliation: Molecular Biology and Genetics
    Research Interests:
    Clinical Interests:
    AdvisorDerek Wildman, Ph.D, Center for Molecular Biology and Genetics

    Outside Interests:
    Academic and Professional Honors:
    2013 Ingenuity Systems Grant Program-Elucidating molecular determinants in PTSD risk and resilience.

  • Mark Pankonin

    Image result for Mark Pankonin

    Education: Undergraduate degree in Physiology from University of Arizona
    Graduate Program Affiliation: Molecular Medicine and Genetics
    Research Interests: Oligodendrocyte lineage development.
    Clinical Interests: Neurology
    Advisor: Jeffrey Loeb, M.D./Ph.D. Molecular Medicine & Genetics, Neurology

    Publications/Presentations:

    • Specific structural features of heparan sulfate proteoglycans potentiate neuregulin-1 signaling. Journal of Biological Chemistry (Feb 05)

    Fellowships: Ruth L. Kirschstein National Research Service Award

    Outside Interests: Making music, film, beach volleyball

    Favorite Aspects of MD PhD Program: Flexibility, autonomy

    Awards:

    • The Frank B. Walker, M.D. Endowed Memorial Prize 2008
    • Dr. A. Ashley Rousuck Award in Internal Medicine 2008

    Mark is also the holder of the prestigious individual training award from the NIH, the Ruth L. Kirschstein National Research Service Award for his research in oligodendrocyte lineage development.

  • Cale Streeter

    Education
    Graduate Program Affiliation
    Research Interests
    Clinical Interests
    Advisor

    Publications:

    Awards/Honors:

    Fellowships:

    Outside Interests: 

    Favorite Aspects of MD PhD Program: 

  • Jeffrey Szymanski

    Education: BS Northern Michigan University, Biochemistry
    Graduate Program Affiliation: Physiology
    Research Interests: Undecided
    Clinical Interests: Undecided
    AdvisorDonald DeGracia, Ph.D., Physiology

     

    Publications:

    1. Szymanski JJ, Jamison JT, Degracia DJ. Texture analysis of poly-adenylated mRNA staining following global brain ischemia and reperfusion. Comput Methods Programs Biomed. 2011 Apr. 6. (Epub ahead of print).
    2. DeGracia OJ, Jamison JT, Szymanski JJ, Lewis N1K. Translation arrest and ribonomics in post-ischemic brain: layers and layers of players. J Neurochem. 2008 Sep;106(6):2288-301. Epub 2008 Jul 8. Review.

    Abstracts:

    1. Szymanski JJ. Binding properties of the Caenorhabditis elegans receptor associated protein. Wayne State University Department of Chemistry, October, 2004. Detroit, MI.
    2. Szymanski JJ. RAP binding to LRP in Caenorhabditis elegans. Argonne Symposium for Undergraduates in Science, Engineering and Mathematics, November, 2004. Argonne National Laboratory, Chigaco, IL.
    3. Jamison JT, Monique KL, Szymanski JJ, Kimball SR, OeGracia OJ. Redistribution Of mRNA After Global Brain Ischemia And Reperfusion. Translational Control, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, 2008; 108.

    Academic and Professional Honors:
    2010-Graduate Student Research Day, 1st Place for Oral Presentation
    2009 – Instructor, Year 1 Endocrinology Conference, Wayne State University School of Medicine
    2008-present – Ad Hoc reviewer-Histology and Histopathology, Journal of Neuropharmacology
    2008 – Invited Presenter, Wayne State Center for Molecular Medicine and Genetics Summer Undergraduate Research Program

    Grants/Fellowships: NIH Fellowships award 2009
    AHA Predoctoral Fellowship, reviews pending.

    Outside Interests: biking, skiing, backpacking

  • Anna Valina-Toth

    Education: WSU, BS, Chemistry UCSB, MS, Chemistry – Thesis: Probing the Ser-Ser-Lys Catalytic Triad Mechanism of Peptide Amidase: Computational Studies of the Ground State, Transistion State, and Intermediate
    Graduate Program Affiliation: Physiology/Internal Medicine
    Research Interests: Undecided
    Clinical Interests: Undecided
     


    Publications/Presentations:

    1. J.M. Flack, A.B. Valina-Toth and S. Nasser; Is Vitamin D an Overlooked Contributor to Excess Cardiovascular Disease in Blacks? Current Cardiovascular Risk Reports; 2008; Volume 2, Issue 4, submitted for publication.
    2. A.L.B. Valina, D. Mazumder-Shivakumar, T.C. Bruice; Probing the Ser-Ser-Lys Catalytic Triad Mechanism of Peptide Amidase: Computational Studies of the Ground State, Transistion State, and Intermediate, Biochemistry; 2004; 43(50); 15657-15672.
    3. A.B. Valina, R. Amunugama, H. Huang, and M.T. Rodgers; Collision-Induced Dissociation and Theoretical Studies of Na -Acetonitrile Complexes, The Journal of Physical Chemistry A; 2001; 105(49); 11057-11068.
    4. G. Vitale, A.B. Valina, H. Huang, R. Amunugama, and M.T. Rodgers; Solvation of Copper Ions by Acetonitrile. Structures and Sequential Binding Energies of Cu (CH3CN)x, x=1-5, from Collision-Induced Dissociation and Theoretical Studies, The Journal of Physical Chemistry A; 2001; 105(50); 11351-11364.

    Book Chapters:

    Flack, JM, Nasser SA, Britton M, Valina-Toth AB, Ahooja V, O’Connor SM: Hypertension in racial and thenic minorities. Chapter 57. In Lip GHY, Hall JE (eds): Comprehensive Hypertension. Philadelphia, Mosby (Elsevier), 2007, pp. 707-718.

    Abstracts:

    1. A.B. Valina-Toth, Z. Lai, R. Quah, M. Britton, W. Yoo, and J.M. Flack. July 2008. The Effects of Vitamin D and Parathyroid Hormone on Blood Pressure and Cardiovascular Function in Normotensive African Americans. Abstract submitted for poster presentation. International Society on Hypertension in Blacks (ISHIB) Meeting 2008, New Orleans, LA.
    2. A.B. Valina-Toth, Z. Lai, R. Quah, W. Yoo, and J.M. Flack. 2008. Vitamin D and Parathyroid Hormone Effects on Body Composition. Abstract for poster presentation. The Endocrine’s Society 90th Annual Meeting 2008, San Francisco, CA.
    3. A.B. Valina-Toth, Z. Lai, R. Quah, M. Britton, W. Yoo, and J.M. Flack.2008. The Effects of Vitamin D and Parathyroid Hormone on Blood PRessure and Cardiovascular Function in Mormotensive Africanan Americans. Abstract for poster presentation. International Society on Hypertention in Blacks (ISHIB) Special Poster Reception at American College of Cardiology (ACC) – 57th Annual Scientific Session 2008, Chicago, IL.
    4. A.B. Valina-Toth, Z. Lai, R. Quah, M. Britton, W. Yoo, and J.M. Flack. March 2008. The Effects of Vitamin D and Parathyroid Hormone on Cardiovascular Function in Normotensive African Americans. Abstract for poster presentation. American Heart Association (AHA) Greater Midwest Affiliate – 2008 Celebration of Science, Ann Arbor, MI.
    5. A.B. Valina-Toth, Z. Lai, R. Quah, M. Britton, W. Yoo, and J.M. Flack. 2008. The Effects of Vitamin D and Parathyroid Hormone on Cardiovascular Function in Normotensive African Americans. Abstract for poster presentation. Centers for Population Health and Health Disparities Meeting (CPHHD), Bethesda, MD.
    6. A.B. Valina-Toth, Z. Lai, R. Quah, W. Yoo, and J.M. Flack 2007. Vitamin D and Parathyroid Hormone Effects on Salt Sensitivity and Vascular Function. Abstract for poster presentation. President’s Biennial Conference on Health Disparities, Wayne State University, Detroit, MI.
    7. A.B. Valina-Toth, Z. Lai, R. Quah, W. Yoo, and J.M. Flack. 2007. Vitamin D and Parathyroid Hormone Effects on Salt Sensitivity and Vascular Function. Abstract for poster presentation. MD PhD Research Day Poster Session, Wayne State University, School of Medicine, Detroit, MI.
    8. A.B. Valina-Toth, Z. Lai, W. Yoo, and J.M. Flack. 2007. Clinical Implications of Vitamin D, Calcium and Parathyroid Hormone Dysregulation. Abstract for oral presentation. Centers for Population Health and Health Disparities Meeting (CPHHD), Boston, MA.
    9. A.B. Valina and M.T. Rodgers. 2001. Absolute Solvation Enthalpies for the Na and Mg Acetonitrile Complexes from Collision-Induced Dissociation and Theoretical Studies. Abstract for poster presentation, Wayne State University Minority Programs Research Day, Detroit, MI.
    10. A.B. Valina and M.T. Rodgers. 2001. Absolute Solvation Enthalpies for the Na and Mg Acetonitrile Complexes from Collision-Induced Dissociation and Theoretical Studies. Abstract for poster presentation, Annual Biomedical Research Conference for Minority Students (ABRCMS), Orlando, FL.
    11. A.B. Valina, G. Vitale and M.T. Rodgers. 2001. Absolute Solvation Enthalpies of Metal Ions by Acetonitrile Determined by Guided Ion Beam Mass Spectrometry. Abstract for poster presentation, 49th American Society for Mass Spectrometry (ASMS) Conference on Mass Spectrometry and Allied Topics, Chicago, IL.
    12. M.T. Rodgers and A.B. Valina. 2001. Absolute Enthalpies of solvation of Na and Mg by Acetonitrile Determined by Guided Ion Beam Tandem Mass Spectrometry and Theoretical Calculations. Abstract for poster presentation, 221st American Chemical Society (ACS) National Meeting, San Diego, CA.

    Fellowships/Awards:

    1. Student Health Professional Award from the International Society on Hypertension in Blacks 2008
    2. Ruth L. Kirschstein National Research Service Awards (NRSA) Predoctoral Fellowship ( NIH, F31), Grant # 1F31ES015935-01A1, 2008-2011
    3. American Heart Association (AHA) Greater Midwest Affiliate Predoctoral Fellowship, Grant # 0715706Z, 2007-2009
    4. Endocrine Summer Research Felloswhip Award from The Endocrine Society, research support and travel grant, summer 2007
    5. Board of Governors Scholarship-Medicine, 2004-2006
    6. Wayne State University Board of Governors Medical School Merit Scholarship, 2004-2011

    Outside Interests: Painting, sight seeing, traveling

  • Alison Van Dyke

     

    Image result for alison van dyke wayne state university

    Education: Post-Baccalaureate Pre-Med Program, University of Pennsylvania, B.A. in Psychology with Concentration in Neural & Behavioral Sciences, Minor in Biology, Bryn Mawr College, Bryn Mawr, PA
    Thesis: The Role of a-2 Noradrenergic Receptor in the Mediation of the Central CRH-NE-NPY Feeding Mechanism in Activity-Based Anorexia in Male Rats, Wendy Sternberg, Ph.D., Haverford College; Haverford, PA
    Graduate Program Affiliation: Cancer Biology
    Research Interests: Neuroimmunology
    Clinical Interests: Neurology, focusing on the overlap between rheumatology & neurology
    AdvisorAnn Schwartz, M.D., M.P.H.,Cancer Biology

    Publications:

    1. Van Dyke AL, Cote ML, Wenzlaff AS, Abram J, Land S, Iyer P, Schwartz AG. Chromosome 5p Region SNPs Are Associated with Risk of NSCLC among Women. Journal of Cancer Epidemiology, Accepted.
    2. Van Dyke AL, Cote ML, Wenzlaff AS, Chen W, Abrams J, Land S, Giroux C, Schwartz AG. Cytokine and Cytokine Receptor SNPs Predict Risk of Non-Small Cell Lung Cancer among Women. Cancer Epidemiology Biomarkers Prevention 2009;18:1829-40.
    3. Van Dyke AL, Cote ML, Wenzlaff AS, Land S, Schwartz AG. Comparison of Allele Frequencies by Race & Implications for Future Studies. Cytokine 2009;46:236-44.
    4. Schwartz AG, Cote ML, Wenzlaff AS, Van Dyke AL, Chen W, Ruckdeschel JC, Gadgell S, Soubani A. Chronic Obstructive Lung Diseases and Risk of Non-Small Cell Lung Cancer in Women. Journal of Thoracic Oncology 2009;4:291-9.
    5. Cote ML, Yoo W, Wenzlaff AS, Prysak GM, Santer S, Claeys GB, Van Dyke AL, Land SJ, Schwartz AG. Tobacco and Estrogen Metabolic Polymorphisms and Risk of Non-Small Cell Lung Cancer in Women. Carcinogenesis 2009;30:626-35.
    6. Van Dyke, A.L., Cote, M.L., Prysak, G., Claeys, G.B., Wenzlaff, A.S., Murphy, V., Lonardo, F., Schwartz, A.G. COX-2/EGFR Expression and Survival among Women with Adenocarcinoma of the Lung. Carcinogenesis 2008;29:1781-7.
    7. Van Dyke, A.L., Cote, M.L., Prysak, G., Claeys, G.B., Wenzlaff, A.S., Schwartz, A.G. Regular Adult Aspirin Use Decreases the Risk of Non-Small Cell Lung Cancer among Women. Cancer Epidemiology Biomarkers & Prevention 2008;17(1):148-57.
    8. Von Feldt JM, Scalzi LV, Cucchiara AJ, Morthala S, Kealey C, Flagg SD, Genin A, Van Dyke AL, Nackos E, Chander A, Gehrie E, Cron RQ, and Whitehead AS. Homocysteine Levels and Disease Duration Independently Correlate with Coronary Artery Calcification in Systemic Lupus Erythematosus Patients. Arthritis & Rheumatism 2006;54(7):2220-7.
    9. Kolasinski SL, Garfinkel M, Gilden-Tsai A, Matz M, Van Dyke A, Schumacher HR. Iyengar Yoga for Osteoarthritis of the Knees: A Pilot Study. The Journal of Alternative and Complementary Medicine 2005;11(4):689-93.

    Book Chapters:

    1. Smith, A.M., Maragos, T., Van Dyke, A.L. Psychology of the Musician. In P. Amadio & R. Tubiana (Eds.), Medical Problems of Instrumentalist Musicians. London : Martin Dunitz Publishers, 1999.

    Abstracts:

    1. Van Dyke AL, Cote ML, Wenzlaff AS, Prysak G, Claeys GB, Land S, Schwartz AG. Cytokine SNPs differentially predict risk of NSCLC in African American and Caucasian women. American Association Cancer Research Meeting, April 2008: 3123.
    2. Flagg SD , Fraterman S, Van Dyke AL , Whitehead AS , Von Feldt JM. Associations between MTHFR C677 Genotype, Homocysteine and Race as Risk Factors Contributing to Premature Cardiovascular Disease in SLE. American College of Rheumatology Meeting, 2003.
    3. Evangelisto A, Kolasinski SL, Garfinkel M, Schumacher HR, Van Dyke AL, Richards C, Hillstrom HH. Changes in Gait Parameters After Participation in a Yoga Program for Treatment of Symptoms of Osteoarthritis (OA) of the Knee: A Pilot Study. OsteoArthritis Research Society International (OARSI) Meeting, 2003.
    4. Flagg SD, Scalzi LV , Van Dyke AL , Von Feldt JM. Homocysteine and Number of Traditional Cardiovascular (CV) Risks Predict Coronary Artery Calcification (CAC) in SLE. American College of Rheumatology Meeting, 2003.

    Invited Presentations:

    1. A three-stage analysis of associations between SNPs in multiple pathways and lung cancer among women. Days of Molecular Medicine 2009: Human Genetics, Stem Cells and Physiology: The Future of individualized medicine. Massachusetts General Hospital/Karolinska Institute, Boston, May 2009.
    2. Cytokine and cytokine receptor polymorphisms differentially predict survival by race among women with NSCLC. American Association Cancer Research Meeting, April 2009.
    3. Cytokine and cytokine receptor polymorphisms differentially predict survival by race among women with NSCLC. Cancer Epidemiology Working Group, University of Michigan, April 2009.
    4. Race, hormones and menopausal status as risk factors in women with NSCLC. North American Association of Central Cancer Registries. Detroit, Michigan. June 7, 2007.

    Reviewer for Journals:
    Cancer Epidemiology Biomarkers Prevention
    Cellular & Molecular Biology Letters
    Experimental Lung Research

    Memberships:
    2007- Associate Member, American Association of Cancer Research
    2007- Associate Member, Karmanos Cancer Institute
    2006- Member, American Association for the Advancement of Science

    Outside Interests: Hiking, watching independent films, listening to the blues, and vegan baking

    Favorite Aspects of MD PhD Program: WSU SOM presents a uniques combination of intensive clinical training unparalleled elsewhere and competitive basic science strengths in my interests

  • Jesse Veenstra

    Education: BS Grand Valley State University, Biomedical Science
    Graduate Program Affiliation: Oncology
    Research Interests: Tumor immunology, autoimmunity, cancer biology
    Clinical Interests: Dermatology
    AdvisorWei-Zen Wei, Ph.D., Oncology

    Research Publications:

    1. Gibson HM, Veenstra JJ, Jones R, Vasihampayan U, Sauerbrey M, Bepler G, et al. Outbred domestic cats for evaluating novel cancer vaccines. Cancer Immunology Research – In Review
    2. Gibson H., Munns S., Freytag S., Barton K., Veenstra J., Bissonette J., Wei W. Immunotherapeutic intervention with oncolytic adenovirus in mouse mammary tumors. OncoImmunology – In Review
    3. Veenstra JJ, Gibson HM, Littrup PJ, Reyes JD, Cher MM, Takashima A, et al. Cryotherapy with concurrent CpG oligonucleotide treatment controls local tumor recurrence and modulates HER2/neu immunity. Cancer Research. 2014 Oct 1;74(19):5409-20.
    4. Veenstra J., Littrup P., Wei W. Amplification of tumor immunity with cryoablation. Cancer Research. 2011 April 15; 71(8 Supplement): 2693

    Oral Presentations:

    1. Veenstra JJ, Gibson HM, Littrup PJ, and Wei WZ. Cryotherapy with concurrent CpG oligonucleotide treatment controls local tumor recurrence and modulates Her2/neu immunity. Wayne State University MD PhD Research Day, 2014. Detroit, MI.
    2. Veenstra JJ, Gibson HM, Littrup PJ, and Wei WZ. Cryotherapy with concurrent CpG oligonucleotide treatment controls local tumor recurrence and modulates Her2/neu immunity. Henry Ford Medical Education Research Forum, 2014. Detroit, MI.
    3. Veenstra J., Gibson H., Jones RF., Piechocki MP., Reyes J., Sauerbrey M., Wei W. Overcoming immune tolerance to self Her2 with heterologous Her2 DNA electrovaccination in domestic cats. Wayne State University MD PhD Retreat, 2013. Detroit, MI.
    4. Veenstra J., Gibson H., Littrup P., Wei W. Manipulation of Tumor Cryoablation Induced Responses. Wayne State Cancer Biology Symposium, 2013. Detroit, MI.
    5. Veenstra J., Gibson H., Littrup P., Wei W. Manipulation of Tumor Cryoablation Induced Responses. Translational Research Cancer Center Consortium, 2013. Seven Springs, PA.
    6. Veenstra J., Gibson H., Littrup P., Wei W. Modulation of Tumor Cryoablation Induced Th2 Response. Autumn Immunology Conference, 2012. Chicago, IL.
    7. Veenstra J., Gibson H., Littrup P., Wei W. Modulation of vaccine induced tumor immunity with cryoablation in wild type and immune tolerant hosts. Translational Research Cancer Center Consortium, 2012. Seven Springs, PA.
    8. Veenstra J., Littrup P., and Wei W. Boosting cancer vaccination with cryoablation: efficacy and challenges. Autumn Immunology Conference, 2011. Chicago, IL.

    Poster Presentations:

    1. Veenstra J., Gibson H., Littrup P., Wei W. Modulation of vaccine induced tumor immunity with cryoablation in wild type and immune tolerant hosts. Karmanos Cancer Institute Wide Retreat, 2012. Detroit, MI.
    2. Veenstra J., Gibson H., Littrup P., Wei W. Modulation of vaccine induced tumor immunity with cryoablation in wild type and immune tolerant hosts. Wayne State Cancer Biology Symposium, 2012. Detroit, MI.
    3. Veenstra J., Littrup P., and Wei W. Impact of cryoablation on vaccine induced tumor immunity. Graduate Student Research Day, 2011. Detroit, MI.
    4. Veenstra J., Littrup P., and Wei W. Amplification of tumor immunity with cryoablation. National MD PhD Student Conference, 2011. Keystone, CO.
    5. Veenstra J., Littrup P., and Wei W. Amplification of tumor immunity with cryoablation. American Association for Cancer Research Annual Meeting, 2011. Orlando, FL.
    6. Veenstra J., Littrup P., and Wei W. Impact of cryoablation on vaccine induced tumor immunity. Wayne State Cancer Biology Symposium, 2011. Detroit, MI.
    7. Veenstra J., Littrup P., and Wei W. Impact of cryoablation on vaccine induced tumor immunity. Translational Research Cancer Center Consortium, 2011. Seven Springs, PA.
    8. Veenstra J., Littrup P., and Wei W. Amplification of tumor immunity with cryoablation. Wayne State University Graduate Exhibition, 2011. Detroit, MI.
    9. Veenstra J., Littrup P., and Wei W. Amplification of tumor immunity with cryoablation. Autumn Immunology Conference, 2010. Chicago, IL.
    10. Veenstra J., Piechocki M., Littrup P., and Wei W. Induction and Modulation of Tumor Immunity with Cryosurgery. Wayne State University Graduate Exhibition, 2010. Detroit, MI.
    11. Veenstra J., Piechocki M., Littrup P., and Wei W. Induction and Modulation of Tumor Immunity with Cryosurgery. The 13th Annual Meeting of the Translational Research Cancer Centers Consortium (TRC3): Immune Suppression and the Tumor Microenvironment, 2010. Columbus, OH.
    12. Veenstra J., LaManna J., Cleary K., Mehedi A., Wencel M., Katyshev V., Trotter R., and Dore-Duffy, P. The Effect of Aging on the CNS Vascular Adaptation to Normobaric Hypoxia. Wayne State University MD PhD Research Day, 2008. Detroit, MI.
    13. Veenstra J., Foot E., and Gow A. Embryogenic Expression of Claudin-11. Wayne State University MD PhD Research Day, 2007. Detroit, MI.
    14. Veenstra J., Smolinski S., and Burg M. Identification of development-specific mRNA splice variants from the rosA gene of Drosophila melanogaster. Midwest Drosophila Conference, 2006. Monticello, IL.

    Academic and Professional Honors:

    2007-14 Overall Honors Year I, II, and III
    2009 Alpha Omega Alpha Honor Society (Junior)
    2007-15 Board of Governors Scholarship
    2007-09 MD PhD Preclinical Academic Excellence Award
    2014 1st place WSU MD PhD Research Day
    2014 1st place research presentation Henry Ford Medical Education Research Forum
    2012 1st place poster award Karmanos Cancer Institute Research Symposium
    2011 2nd place Wayne State University Cancer Biology Symposium
    2010 2nd place Wayne State University Graduate Exhibition

    Memberships:

    2013 Dermatology Interest Group
    2009 Alpha Omega Alpha Honor Society
    2007 American Medical Association
    2007 American Medical Student Association
    2007 Michigan State Medical Society Member

    Fellowships:
    2011-16 “Treg-Th17 Axis Modulation and Induction of Tumor Immunity with Cryosurgery”
    NIH/NIA F30 AG038138 fellowship (Veenstra J.) – MD PhD fellowship

    2010-11 Training Program in the Biology of Cancer – Trainee
    NIH/NCI T32-CA009531 (Matherly L.)

    Favorite Aspects of MD PhD Program: The program has been very supportive and allowed me to pursue the research I’m passionate about.

  • Paula J. Whittington

    Provider photo for Paula Whittington

     

    Education: B.S. in Biology at the University of Maryland, Baltimore County
    Graduate Program Affiliation: Immunology & Microbiology Department
    Research Interests: Immunotherapy and Autoimmune Diseases
    Clinical Interests: Transplant Surgery, Oncology, Autoimmunity and Infectious Disease
    Advisor: Wei-Zen Wei, Ph.D., Cancer Biology and Immunology/Microbiology Department

    Grants/Fellowships: IMSD Support Grant

    Outside Interests: Martial Arts

  • Chaowen Wu

    Year in Program: M4
    Education: BS University of Michigan, Biopsychology and minor in Philosophy
    Graduate Program Affiliation: Anatomy & Cell Biology
    Clinical Interests: Surgery
    AdvisorZhuo-Hua Pan, Anatomy & Cell Biology

     

    Academic and Professional Honors:
    Graduate Student Research Day, 1st Place, Poster Presentation
    National Eye Institute Travel Grant Award, 2010
    The Association for Research in Vision and Ophthalmology Member, 2010
    Society for Neuroscience Member, 2007
    Board of Governors Scholarship, 2005-present

    University Honors, University of Michigan, 2001-2004
    Golden Key Honors Society, 2001-2004
    Biomedical Research Fellowship, 2002-2003
    Angell B. Scholar Award, 2000

    Publications & Abstracts:

    1. Wu C, Ivanova E, Cui J, Lu Q, Pan ZH. Action Potential Generation at an Axon Initial Segment-Like Process in the Axonless Retinal AII Amacrine Cell. Journal of Neuroscience. 2011;31(41):14654-14659.
    2. Siddiqui A, Cipriano J. Wu C, Tepper D. (Apr. 2012). Tissue Matrix Allograft Stretch in Breast Reconstruction. American Association of Plastic Surgeons, San Francisco, CA.
    3. Wu C, Ivanova E, Cui J, Pan ZH. (May 2011). Sodium channel clustering in an AII amacrine cell process revealed by targeting Chop2-GFP with the ankyrin binding domain motif. The Association for Research in Vision and Opthalmology Annual Meeting, Fort Lauderdale, FL.
    4. Wu C, Ivanova E, Cui J, Pan ZH. (Nov. 2010). Sodium channel clustering in an AII amacrine cell process revealed by targeting Chop2-GFP with the ankyrin binding domain motif. Great Lakes Vision Research Conference, Ann Arbor, MI.
    5. Wu C, Ivanova E, Cui J, Pan ZH. (Jul. 2010). Sodium channel clustering in an AII amacrine cell process revealed by targeting Chop2-GFP with the ankyrin binding domain motif. Federation of American Societies for Experimental Biology, Saxtons River, VT.
    6. Wu C, Ivanova E, Zhang Y, Pan ZH. (May 2010). AAV-mediated subcellular targeting of Chop2-GFP in retinal ganglion cells. The Association for Research in Vision and Opthalmology Annual Meeting, Fort Lauderdale, FL.
    7. Wu C, Pan ZH. (Sep. 2009). Recreating retinal center-surround inhibition organization through the use of protein sorting motifs. Graduate Student Research Day, Detroit, MI.
    8. Bi A, Cui J, Ma YP, Ivanova E, Pu ML, Dizhoor AM, Wu C, and Pan ZH. (Sep. 2007). Ectopic Expression of Channelrhodopsin-2 Restores Visual Responses in Mice with Photoreceptor Degeneration. Graduate Student Research Day, Detroit, MI.

    Outside Interests: Painting, horseback riding, good food